Formobactin, a Novel Free Radical Scavenging and Neuronal Cell Protecting Substance from Nocardia sp.

YASUNOBU MURAKAMI; SHINICHIRO KATO; MIIKO NAKAJIMA; MICHIKO MATSUOKA; HIROYUKI KAWAI; KAZUO SHIN-YA; HARUO SETO

doi:10.7164/antibiotics.49.839

Formobactin, a Novel Free Radical Scavenging and Neuronal Cell Protecting Substance from Nocardia sp.

YASUNOBU MURAKAMI, SHINICHIRO KATO, MIIKO NAKAJIMA, MICHIKO MATSUOKA, HIROYUKI KAWAI, KAZUO SHIN-YA, HARUO SETO

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 9 Pages 839-845

DOI https://doi.org/10.7164/antibiotics.49.839

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Abstract

Formobactin, a new free radical scavenger, was isolated from the culture of Nocardia sp. strain ND20. The structure of formobactin was determined to be a member of the nocobactin group antibiotics. Formobactin inhibited lipid peroxidation in rat brain homogenate. Formobactin also showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.

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