BICYCLOMYCIN, A NEW ANTIBIOTIC
II. STRUCTURAL ELUCIDATION AND ACYL DERIVATIVES
1972 Volume 25 Issue 10 Pages 576-581
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1972 Volume 25 Issue 10 Pages 576-581
The structure of bicyclomycin, a novel antibiotic, was largely elucidated by nuclear magnetic resonance spectroscopy and established finally as 8, 10-diaza-6-hydroxy-5-methylene-l-(2'-methyl-1', 2', 3'-trihydroxy-propyl)-2-oxabicyclo [4, 2, 2] decan-7, 9-dione by X-ray crystallographic diffraction analysis. A number of its acyl derivatives were prepared and studied biologically. The relationship between the structure of the acyl derivatives and the rate of urinary excretion was also examined.
