The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
OKILACTOMYCIN, A NOVEL ANTIBIOTIC PRODUCED BY A STREPTOMYCES SPECIES
I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
HARUMITSU IMAI, KEN-ICHI SUZUKI, MOTO MORIOKA, Yousou NUMASAKI, SHIGENOBU KADOTA, KOJI NAGAI, TSUTOMU SATO, MASARU IWANAMI, TAKESHI SAITO
Author information
JOURNAL FREE ACCESS

1987 Volume 40 Issue 11 Pages 1475-1482

Details
Abstract

Okilactomycin, a novel antibiotic, was isolated from the culture filtrate of a strain of actinomycetes. The producing organism, strain YP-02908L, was identified as Streptomyces griseoflavus subsp. zamamiensis subsp. nov. The antibiotic was extracted with ethyl acetate and purified by silica gel column chromatography. It was obtained as colorless prisms from a dichloromethane solution. It exhibited weak antimicrobial activity against Grampositive organisms in vitro. It also exhibited antitumor activity against Ehrlich ascites carcinoma in vivo. The apparent molecular formula of okilactomycin was determined as C24H32O6. It is a new member of the lactone group antibiotics.

Content from these authors
© Japan Antibiotics Research Association
Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Journal of Antibiotics, Series A

Share this page
feedback
 Top