SYNERAZOL, A NEW ANTIFUNGAL ANTIBIOTIC

OSAMU ANDO; HITOMI SATAKE; MUTSUO NAKAJIMA; AKIRA SATO; TAKEMICHI NAKAMURA; TAKESHI KINOSHITA; KOUHEI FURUYA; TATSUO HANEISHI

doi:10.7164/antibiotics.44.382

OSAMU ANDO, HITOMI SATAKE, MUTSUO NAKAJIMA, AKIRA SATO, TAKEMICHI NAKAMURA, TAKESHI KINOSHITA, KOUHEI FURUYA, TATSUO HANEISHI

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 4 Pages 382-389

DOI https://doi.org/10.7164/antibiotics.44.382

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Abstract

Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.

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