PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

SATOSHI OMURA; DIDIER VAN DER PYL; JUNJI INOKOSHI; YOKO TAKAHASHI; HIDEO TAKESHIMA

doi:10.7164/antibiotics.46.222

PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE

I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

SATOSHI OMURA, DIDIER VAN DER PYL, JUNJI INOKOSHI, YOKO TAKAHASHI, HIDEO TAKESHIMA

Author information

JOURNAL FREE ACCESS

1993 Volume 46 Issue 2 Pages 222-228

DOI https://doi.org/10.7164/antibiotics.46.222

Details

Abstract

Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC₅₀-100nM).

Corresponding author

Register with J-STAGE for free!