Xanthofulvin, a Novel Semaphorin Inhibitor Produced by a Strain of Penicillium

KAZUO KUMAGAI; NOBUO HOSOTANI; KAORU KIKUCHI; TORU KIMURA; IKUTARO SAJI

doi:10.7164/antibiotics.56.610

Xanthofulvin, a Novel Semaphorin Inhibitor Produced by a Strain of Penicillium

KAZUO KUMAGAI, NOBUO HOSOTANI, KAORU KIKUCHI, TORU KIMURA, IKUTARO SAJI

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 7 Pages 610-616

DOI https://doi.org/10.7164/antibiotics.56.610

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Abstract

A new semaphorin inhibitor xanthofulvin was isolated from the cultured broth of a fungus Penicillium sp. SPF-3059 along with a known compound vinaxanthone by solvent extraction and bioassay-guided fractionation. The tautomeric structure of xanthofulvin was determined by spectroscopic analyses. The two compounds exhibited significant semaphorin inhibitory activity with IC₅₀ values of 0.09 and 0.1μg/ml, respectively, in semaphorin3A-induced growth cone collapse assay using cultured chick dorsal root ganglia neurons.

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