Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Literature Search
2.2. Inclusion and Exclusion Criteria
2.3. Data Extraction
2.4. Statistical Analysis
3. Results
3.1. Literature Search
3.2. Characteristics of the Study Population
3.3. Detection Accuracy of Lymph Node Metastasis Overall
3.4. Detection of Lymph Node Metastasis Sub-Grouped by Operator
3.5. Heterogeneity Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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First Author | Year | Country | Study Period | Study Design | Sample Size | Number of Lymph Nodes | Sonographer Qualification |
---|---|---|---|---|---|---|---|
Lu [19] | 2022 | China | 01/2018–01/2020 | Retro | 185 | 185 | US Technician |
Liu [18] | 2021 | China | 04/2016–05/2018 | Retro | 600 | 661 | Radiology |
Gao [20] | 2020 | China | 05/2017–07/2017 | Pro | 501 | 618 | Radiology |
Zhang [21] | 2020 | China | 01/2018–09/2018 | Retro | 665 | 665 | US Technician |
Li [40] | 2019 | China | 01/2017–12/2017 | Pro | 30 | 99 | US Technician |
Lee [22] | 2019 | Korea | 12/2014–12/2016 | Retro | 218 | 479 | Radiology |
Eun [23] | 2018 | Korea | 01/2013–12/2015 | Retro | 302 | 1128 | Radiology |
Hong [24] | 2017 | China | 01/2014–09/2016 | Pro | 253 | 319 | Radiology |
Lee [25] | 2017 | Korea | 11/2011–12/2012 | Pro | 351 | 801 | Radiology |
Patel [26] | 2016 | USA | 01/2011–12/2011 | Retro | 44 | 71 | Radiology |
Na [27] | 2015 | Korea | 03/2011–02/2012 | Retro | 176 | 352 | Radiology |
Choi [28] | 2015 | Korea | 12/2012–04/2013 | Retro | 625 | 1250 | Radiology |
Khokhar [29] | 2015 | USA | 2004–2014 | Retro | 51 | 227 | Radiology |
Xiang [30] | 2014 | China | 05/2012–01/2014 | Retro | 53 | 82 | Radiology |
Shim [31] | 2013 | Korea | 2006–2010 | Retro | 143 | 715 | US Technician |
Lee [32] | 2013 | Korea | 01/2007–5/2010 | Retro | 252 | 558 | Radiology |
Lesnik [13] | 2013 | USA | 2003–2008 | Pro | 95 | 196 | US Technician |
Lee [41] | 2012 | USA | 2000–2008 | Retro | 109 | 109 | Endocrine Surgeon |
Hwang & Orloff [33] | 2011 | USA | 10/2004–12/2007 | Retro | 99 | 141 | Head and Neck Surgeon |
Park [34] | 2009 | Korea | 11/2006–03/2007 | Pro | 94 | 147 | Radiology |
Choi [39] | 2009 | Korea | 02/2006–04/2007 | Retro | 299 | 352 | Radiology |
Sugitani [35] | 2008 | Japan | 1993–2001 | Pro | 361 | 357 | Radiology |
Ahn [36] | 2008 | Korea | 01/2005–12/2005 | Retro | 37 | 181 | Radiology |
Kim [37] | 2008 | Korea | 04/2006–10/2006 | Retro | 165 | 277 | Radiology |
Gonzalez [38] | 2007 | Chile | 01/2006–06/2006 | Pro | 60 | 60 | Radiology |
Diagnostic Parameter | Meta-Analysis Pooled Estimate (95%CI) |
---|---|
Sensitivity | 59% (58–60%) |
Specificity | 85% (84–86%) |
Positive Likelihood Ratio | 3.66 (2.88–4.66) |
Negative Likelihood Ratio | 0.49 (0.42–0.57) |
Diagnostic Odds Ratio | 8.04 (5.86–11.03) |
Area Under the Curve (SE) | 0.800 ± 0.022 |
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Issa, P.P.; Mueller, L.; Hussein, M.; Albuck, A.; Shama, M.; Toraih, E.; Kandil, E. Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis. Biomedicines 2022, 10, 2575. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102575
Issa PP, Mueller L, Hussein M, Albuck A, Shama M, Toraih E, Kandil E. Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis. Biomedicines. 2022; 10(10):2575. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102575
Chicago/Turabian StyleIssa, Peter P., Lauren Mueller, Mohammad Hussein, Aaron Albuck, Mohamed Shama, Eman Toraih, and Emad Kandil. 2022. "Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis" Biomedicines 10, no. 10: 2575. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102575