N6-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication
Abstract
:Simple Summary
Abstract
1. Introduction
2. YTHDF1 Is a Major m6A Reader Involved in mRNA Translation
3. YTHDF1 in Gastrointestinal Cancers
3.1. YTHDF1 in Gastric Cancer
3.2. YTHDF1 in Colorectal Cancer
3.3. YTHDF1 in Hepatocellular Carcinoma
3.4. YTHDF1 in Other Gastrointestinal Cancers
4. Clinical Implications of YTHDF1
4.1. The Impact of YTHDF1 on Chemotherapy
4.2. The Impact of YTHDF1 on Immunotherapy
5. Conclusions and Perspectives
Cancer | Expression | Function | Molecular Targets | Reference |
---|---|---|---|---|
Esophageal Cancer | Increased | Oncogenic | NA | [68,84,85] |
Gastric Cancer | Increased | Oncogenic | PD-1, PD-L1, CTLA-4 | [13,18] |
FZD7/β-catenin | [11] | |||
SPHK2 | [16] | |||
JAK/STAT1 | [17] | |||
Colorectal Cancer | Increased | Oncogenic | FZD9/WNT6/β-catenin | [24] |
c-MYC | [27] | |||
ARHGEF2 | [29] | |||
TCF4/DVL3/FZD7/β-catenin | [31,32] | |||
TEAD1 | [33] | |||
TRAF6, DDX60, NLRP3 | [36,37,38] | |||
Hepatocellular Carcinoma | Increased | Oncogenic | SNAI1 | [10] |
PI3K/AKT/mTOR | [55] | |||
EGFR | [57] | |||
AKT/GSK-3β/β-catenin | [56] | |||
FZD5/β-catenin | [54] | |||
PD-L1, mTOR, WNT | [47] | |||
HIF-1α, ATG2A, ATG14 | [59] | |||
TGF-β, WNT | [61] | |||
Pancreatic Cancer | Decreased | Tumor Suppressive | NA | [63,64,65,66] |
Author Contributions
Funding
Conflicts of Interest
References
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Chen, D.; Cheung, H.; Lau, H.C.-H.; Yu, J.; Wong, C.C. N6-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication. Cancers 2022, 14, 3489. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143489
Chen D, Cheung H, Lau HC-H, Yu J, Wong CC. N6-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication. Cancers. 2022; 14(14):3489. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143489
Chicago/Turabian StyleChen, Danyu, Henley Cheung, Harry Cheuk-Hay Lau, Jun Yu, and Chi Chun Wong. 2022. "N6-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication" Cancers 14, no. 14: 3489. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143489