Disproportion in Pericyte/Endothelial Cell Proliferation and Mechanisms of Intussusceptive Angiogenesis Participate in Bizarre Vessel Formation in Glioblastoma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Human Tissue Samples
2.2. Light Microscopy
2.3. Immunohistochemistry
2.4. Immunofluorescence in Confocal Microscopy
2.5. Evaluation of the PI in the BM of GBM
3. Results
3.1. Microvascular Patterns in GBM
3.2. Cellular Components of Bizarre Vessels in GBM
3.3. Neoplastic Glial Cells and BM in GBM
3.4. Microglia and BM in GBM
3.5. Pericyte and EC Proliferation in the BM
3.6. Intravascular Pillars
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Type I BM | Type II BM | |
---|---|---|
Overall PI | Mean 43.57 ± 9.5 | Mean 3.41 ± 0.76 |
Pericyte PI | Mean 42.11 ± 5.76 | Mean 1.12 ± 0.21 |
EC PI | Mean 0.88 ± 0.29 | Mean 2.21 ± 0.88 |
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Díaz-Flores, L.; Gutiérrez, R.; González-Gómez, M.; García, M.-d.-P.; Díaz-Flores, L., Jr.; González-Marrero, I.; Ávila, J.; Martín-Vasallo, P. Disproportion in Pericyte/Endothelial Cell Proliferation and Mechanisms of Intussusceptive Angiogenesis Participate in Bizarre Vessel Formation in Glioblastoma. Cells 2021, 10, 2625. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102625
Díaz-Flores L, Gutiérrez R, González-Gómez M, García M-d-P, Díaz-Flores L Jr., González-Marrero I, Ávila J, Martín-Vasallo P. Disproportion in Pericyte/Endothelial Cell Proliferation and Mechanisms of Intussusceptive Angiogenesis Participate in Bizarre Vessel Formation in Glioblastoma. Cells. 2021; 10(10):2625. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102625
Chicago/Turabian StyleDíaz-Flores, Lucio, Ricardo Gutiérrez, Miriam González-Gómez, María-del-Pino García, Lucio Díaz-Flores, Jr., Ibrahim González-Marrero, Julio Ávila, and Pablo Martín-Vasallo. 2021. "Disproportion in Pericyte/Endothelial Cell Proliferation and Mechanisms of Intussusceptive Angiogenesis Participate in Bizarre Vessel Formation in Glioblastoma" Cells 10, no. 10: 2625. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102625