The Regulatory Activity of Noncoding RNAs in ILCs
Abstract
:1. Introduction
2. Regulation of ILC Activity by miRNAs
2.1. Properties of miRNAs
2.2. miRNAs and ILCs
3. Regulation of ILC Activity by lncRNAs
3.1. Properties of lncRNAs
3.2. LncRNAs and ILCs
4. Regulation of ILC Activity by circRNAs
4.1. Properties of circRNAs
4.2. circRNAs and ILCs
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ILC | innate lymphoid cell |
TF | transcription factor |
NK | natural killer |
ILC1 | type-1 innate lymphoid cell |
IFN | interferon |
TGF-β | transforming growth factor-β |
ILC2 | type-2 innate lymphoid cell |
IL | interleukin |
ILC3 | type-3 innate lymphoid cell |
LTi | lymphoid tissue inducer |
LDTF | lineage defining TF |
ncRNA | noncoding RNA |
miRNA | microRNA |
rRNA | ribosomal RNA |
tRNA | transfer RNA |
lncRNA | long ncRNA |
circRNA | circular RNA |
RISC | RNA-induced silencing complex |
H3K27me3 | trimethylation of lysine 27 of the histone 3 |
ILCp | ILC precursor |
a-LP | a-lymphoid progenitors |
dILC3 | decidual ILC3 |
dNK | decidual NK |
pbNK | peripheral blood NK cells |
cbNK | cord blood NK |
ecircRNAs | exonic circRNAs |
ciRNAs | circular intronic RNAs |
EIciRNAs | exonic–intronic circRNAs |
tricRNAs | tRNA intronic circRNAs. |
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ncRNAs | Cell | Regulator | Target | Biological Effect | References |
---|---|---|---|---|---|
miRNAs | |||||
miRNA-142-3p | ILC1 | IL-15 | TGFBR1 | TGFβ signalling | [58] |
miRNA-142-5p | ILC1 | IL-15 | SOCS1 | IL-15 signalling | [58] |
miRNA-142 | ILC2 | - | SOCS1 | γc-cytokine signalling | [62] |
miRNA-142 | ILC2 | - | GFI1 | ST2-IL-33 signalling | [62] |
miRNA-19a | ILC2 | - | SOCS1 | JAK/STAT signalling | [63] |
miRNA-19a | ILC2 | - | TNFAIP3 | IL-13 and IL-5 signalling | [63] |
miRNA-155 | ILC2 | IL-33 | c-Maf | IL-4, IL-5, IL-9 and IL-13 production | [11,69] |
miRNA-146a | ILC2 | - | TRAF6, IRAK1 | ST2-IL-33 signalling | [71] |
lncRNAs | |||||
lnc-CD56 | NK | - | CD56 | NK cell differentiation | [86] |
lnc-GAS5 | NK | IL-2 | RUNX3 | NK cell cytotoxicity | [91] |
lnc-ifng-as | NK | STAT-4/ T-BET, IL-12/IL-18 | IFN-γ | IFN-γ production | [84,85] |
Rroid locus | ILC1 | IL-15 | Id2 | T and B cell lineage | [92] |
lncKdm2b | ILC3 | - | Zfp929 | ILC3 proliferation | [95] |
circRNAs | |||||
circUHRF1 | NK | Tumor | TIM-3 | IFN-γ and TNF-α production | [104] |
circZbtb20 | ILC3 | - | Nr4a | ILC3 proliferation | [105] |
circKcnt2 | ILC3 | Inflammation | Batf | IL-17a expression and ILC3 activation | [106] |
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Grimaldi, A.; Pietropaolo, G.; Stabile, H.; Kosta, A.; Capuano, C.; Gismondi, A.; Santoni, A.; Sciumè, G.; Fionda, C. The Regulatory Activity of Noncoding RNAs in ILCs. Cells 2021, 10, 2742. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102742
Grimaldi A, Pietropaolo G, Stabile H, Kosta A, Capuano C, Gismondi A, Santoni A, Sciumè G, Fionda C. The Regulatory Activity of Noncoding RNAs in ILCs. Cells. 2021; 10(10):2742. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102742
Chicago/Turabian StyleGrimaldi, Alessio, Giuseppe Pietropaolo, Helena Stabile, Andrea Kosta, Cristina Capuano, Angela Gismondi, Angela Santoni, Giuseppe Sciumè, and Cinzia Fionda. 2021. "The Regulatory Activity of Noncoding RNAs in ILCs" Cells 10, no. 10: 2742. https://0-doi-org.brum.beds.ac.uk/10.3390/cells10102742