Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury
Abstract
:1. Introduction
2. Methods
3. Literature Review
3.1. Sequelae of Childhood Brain Injury
3.1.1. Cognitive Sequelae
3.1.2. Psychiatric Sequelae
3.1.3. Other Sequelae
3.2. Academic Outcomes among Youth with Brain Injury
3.2.1. Academic Achievement
3.2.2. Need for Academic Supports
3.2.3. School Engagement
3.2.4. Moderators of Academic Outcomes
3.3. Special Education Law
3.3.1. Individuals with Disabilities Education Act (IDEA)
3.3.2. Section 504 of 1973 Rehabilitation Act
4. Current Status and Future Directions
4.1. Current Limitations
4.2. Avenues for Next Steps
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Hall, T.A.; Leonard, S.; Bradbury, K.; Holding, E.; Lee, J.; Wagner, A.; Duvall, S.; Williams, C.N. Post-intensive care syndrome in a cohort of infants & young children receiving integrated care via a pediatric critical care & neurotrauma recovery program: A pilot investigation. Clin. Neuropsychol. 2020, 36, 639–663. [Google Scholar]
- Langlois, J.A.; Rutland-Brown, W.; Thomas, K.E. The incidence of traumatic brain injury among children in the United States: Differences by race. J. Head Trauma Rehabil. 2005, 20, 229–238. [Google Scholar] [CrossRef] [PubMed]
- Haarbauer-Krupa, J.; Lee, A.H.; Bitsko, R.H.; Zhang, X.; Kresnow-Sedacca, M.J. Prevalence of parent-reported traumatic brain injury in children and associated health conditions. JAMA Pediatr. 2018, 172, 1078–1086. [Google Scholar] [CrossRef] [PubMed]
- Schoenberg, B.S.; Mellinger, J.F.; Schoenberg, D.G. Cerebrovascular disease in infants and children: A study of incidence, clinical features, and survival. Neurol 1978, 28, 763. [Google Scholar] [CrossRef]
- Lynch, J.K.; Hirtz, D.G.; DeVeber, G.; Nelson, K.B. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 2002, 109, 116–123. [Google Scholar] [CrossRef]
- Deveber, G. The epidemiology of childhood stroke. In Stroke and Cerebrovascular Disease in Childhood; Ganesan, V., Kirkham, F., Eds.; Mac Keith Press: London, UK, 2011; pp. 22–26. [Google Scholar]
- Biondi, E.A.; Lee, B.; Ralston, S.L.; Winikor, J.M.; Lynn, J.F.; Dixon, A.; McCulloh, R. Prevalence of Bacteremia and Bacterial Meningitis in Febrile Neonates and Infants in the Second Month of Life. JAMA Netw. Open 2019, 2, e190874. [Google Scholar] [CrossRef] [PubMed]
- Martinez, E.; Mintegi, S.; Vilar, B.; Martinez, M.J.; Lopez, A.; Catediano, E.; Gomez, B. Prevalence and Predictors of Bacterial Meningitis in Young Infants With Fever Without a Source. Pediatr. Infect. Dis. J. 2015, 34, 494–498. [Google Scholar] [CrossRef]
- Wintemute, G.J. Childhood drowning and near-drowning in the United States. Am. J. Dis. Child. 1990, 144, 663–669. [Google Scholar] [CrossRef]
- Hall, T.A.; Greene, R.K.; Lee, J.B.; Leonard, S.; Bradbury, K.R.; Drury, K.; Recht, G.; Randall, J.; Norr, M.E.; Williams, C.N. Post-Intensive Care Syndrome in a Cohort of School-Aged Children and Adolescent ICU Survivors: The Importance of Follow-up in the Acute Recovery Phase. J. Pediatr. Intensive Care 2022, 36, 639–663. [Google Scholar] [CrossRef]
- Watson, R.S.; Choong, K.; Colville, G.; Crow, S.; Dervan, L.A.; Hopkins, R.O.; Knoester, H.; Pollack, M.M.; Rennick, J.; Curley, M.A. Life after Critical Illness in Children—Toward an Understanding of Pediatric Post-intensive Care Syndrome. J. Pediatr. 2018, 198, 16–24. [Google Scholar] [CrossRef]
- Bradbury, K.R.; Williams, C.; Leonard, S.; Holding, E.; Turner, E.; Wagner, A.E.; Piantino, J.; Luther, M.; Hall, T.A. Emotional aspects of pediatric post-intensive care syndrome following traumatic brain injury. J. Child Adolesc. Trauma 2021, 14, 177–187. [Google Scholar] [CrossRef]
- Jantz, P.B.; Coulter, G.A. Child and adolescent traumatic brain injury: Academic, behavioural, and social consequences in the classroom. Support Learn. 2007, 22, 84–89. [Google Scholar] [CrossRef]
- Rode, C.; McCart, M.; Glang, A. School-based Interventions. Cog. Rehabil. Pediatr. Neurol. Disord. 2018, 31, 169–189. [Google Scholar]
- Ewing-Cobbs, L.; Prasad, M.R.; Landry, S.H.; Kramer, L.; DeLeon, R. Executive Functions Following Traumatic Brain Injury in Young Children: A Preliminary Analysis. Dev. Neuropsychol. 2004, 26, 487–512. [Google Scholar] [CrossRef] [PubMed]
- Deotto, A.; Westmacott, R.; Fuentes, A.; deVeber, G.; Desrocher, M. Does stroke impair academic achievement in children? The role of metacognition in math and spelling outcomes following pediatric stroke. J. Clin. Exp. Neuropsychol. 2018, 41, 257–269. [Google Scholar] [CrossRef] [PubMed]
- Prasad, M.R.; Swank, P.R.; Ewing-Cobbs, L. Long-Term School Outcomes of Children and Adolescents with Traumatic Brain Injury. J. Head Trauma Rehabil. 2017, 32, E24–E32. [Google Scholar] [CrossRef]
- Yvon, E.; Lamotte, D.; Tiberghien, A.; Godard, I.; Mardaye, A.; Laurent-Vannier, A.; Chevignard, M. Long-term motor, functional, and academic outcome following childhood ischemic and hemorrhagic stroke: A large rehabilitation center-based retrospective study. Dev. Neurorehabilit. 2018, 21, 83–90. [Google Scholar] [CrossRef] [PubMed]
- Nagele, D.A.; McCart, M.; Hooper, S.R. A call for implementing preferred practices for brain injury screening in youth to improve transition. Neurorehabilitation 2018, 42, 289–298. [Google Scholar] [CrossRef]
- Lundine, J.P.; Todis, B.; Gau, J.M.; McCart, M.; Wade, S.L.; Yeates, K.O.; Glang, A. Return to School Following TBI: Educational Services Received 1 Year After Injury. J. Head Trauma Rehabil. 2020, 36, E89–E96. [Google Scholar] [CrossRef]
- Todis, B.; McCart, M.; Glang, A. Hospital to school transition following traumatic brain injury: A qualitative longitudinal study. Neurorehabilitation 2018, 42, 269–276. [Google Scholar] [CrossRef]
- Di Stefano, G.; Bachevalier, J.; Levin, H.S.; Song, J.X.; Scheibel, R.S.; Fletcher, J.M. Volume of focal brain lesions and hippocampal formation in relation to memory function after closed head injury in children. J. Neurol. Neurosurg. Psychiatry 2000, 69, 210–216. [Google Scholar] [CrossRef]
- Wozniak, J.R.; Krach, L.; Ward, E.; Mueller, B.A.; Muetzel, R.; Schnoebelen, S.; Kiragu, S.; Lim, K.O. Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) study. Arch. Clin. Neuropsychol. 2007, 22, 555–568. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Abgottspon, S.; Thaqi, Q.; Steiner, L.; Slavova, N.; Grunt, S.; Steinlin, M.; Everts, R. Effect of age at pediatric stroke on long-term cognitive outcome. Neurol 2022, 98, e721–e729. [Google Scholar] [CrossRef] [PubMed]
- Akshoomoff, N.A.; Feroleto, C.C.; Doyle, R.E.; Stiles, J. The impact of early unilateral brain injury on perceptual organization and visual memory. Neuropsychologia 2002, 40, 539–561. [Google Scholar] [CrossRef]
- Babikian, T.; Asarnow, R. Neurocognitive outcomes and recovery after pediatric TBI: Meta-analytic review of the literature. Neuropsychology 2009, 23, 283. [Google Scholar] [CrossRef] [PubMed]
- Chilosi, A.M.; Cipriani, P.; Bertuccelli, B.; Pfanner, L.; Cioni, G. Early cognitive and communication development in children with focal brain lesions. J. Child Neurol. 2001, 16, 309–316. [Google Scholar] [CrossRef]
- Koomen, I.; Van Furth, A.M.; Kraak, M.A.; Grobbee, D.E.; Roord, J.J.; Jennekens-Schinkel, A. Neuropsychology of academic and behavioural limitations in school-age survivors of bacterial meningitis. Dev. Med. Child Neurol. 2004, 46, 724–732. [Google Scholar] [CrossRef] [PubMed]
- Johansson Kostenniemi, U.; Bazan, A.; Karlsson, L.; Silfverdal, S.A. Psychiatric disabilities and other long-term consequences of childhood bacterial meningitis. Pediatr. Infect. Dis. J. 2020, 40, 26–31. [Google Scholar] [CrossRef]
- Peterson, R.K.; Williams, T.S.; McDonald, K.P.; Dlamini, N.; Westmacott, R. Cognitive and academic outcomes following childhood cortical stroke. J. Child Neurol. 2019, 34, 897–906. [Google Scholar] [CrossRef] [PubMed]
- Suominen, P.K.; Sutinen, N.; Valle, S.; Olkkola, K.T.; Lönnqvist, T. Neurocognitive long term follow-up study on drowned children. Resuscitation 2014, 85, 1059–1064. [Google Scholar] [CrossRef]
- Sreenan, C.; Bhargava, R.; Robertson, C.M. Cerebral infarction in the term newborn: Clinical presentation and long-term outcome. J. Pediatrics 2000, 137, 351–355. [Google Scholar] [CrossRef] [PubMed]
- Westmacott, R.; Askalan, R.; Macgregor, D.; Anderson, P.; Deveber, G. Cognitive outcome following unilateral arterial ischaemic stroke in childhood: Effects of age at stroke and lesion location. Dev. Med. Child Neurol. 2010, 52, 386–393. [Google Scholar] [CrossRef] [PubMed]
- Muscara, F.; Catroppa, C.; Anderson, V. Social problem-solving skills as a mediator between executive function and long-term social outcome following pediatric traumatic brain injury. J. Neuropsychol. 2008, 2, 445–461. [Google Scholar] [CrossRef]
- Rivella, C.; Viterbori, P. Executive function following pediatric stroke. A systematic review. Child Neuropsychol. 2021, 27, 209–231. [Google Scholar] [CrossRef]
- Zamani, A.; Ryan, N.P.; Wright, D.K.; Caeyenberghs, K.; Semple, B.D. The impact of traumatic injury to the immature human brain: A scoping review with insights from advanced structural neuroimaging. J. Neurotrauma 2020, 37, 724–738. [Google Scholar] [CrossRef] [PubMed]
- Goh, M.S.L.; Looi, D.S.H.; Goh, J.L.; Sultana, R.; Goh, S.S.M.; Lee, J.H.; Chong, S.L. The impact of traumatic brain injury on neurocognitive outcomes in children: A systematic review and meta-analysis. J. Neurol. Neurosurg. Psychiatry 2021, 92, 847–853. [Google Scholar] [CrossRef]
- Roncadin, C.; Guger, S.; Archibald, J.; Barnes, M.; Dennis, M. Working memory after mild, moderate, or severe childhood closed head injury. Dev. Neuropsychol. 2004, 25, 21–36. [Google Scholar] [CrossRef]
- Keenan, H.T.; Clark, A.E.; Holubkov, R.; Cox, C.S.; Ewing-Cobbs, L. Trajectories of children’s executive function after traumatic brain injury. JAMA Netw. Open 2021, 4, e212624. [Google Scholar] [CrossRef]
- Max, J.E.; Robin, D.A.; Taylor, H.G.; Yeates, K.O.; Fox, P.T.; Lancaster, J.L.; Manes, F.F.; Mathews, K.; Austermann, S. Attention function after childhood stroke. J. Int. Neuropsychol. Soc. 2004, 10, 976–986. [Google Scholar] [CrossRef]
- Studer, M.; Boltshauser, E.; Mori, A.C.; Datta, A.; Fluss, J.; Mercati, D.; Hackenberg, A.; Keller, E.; Maier, O.; Marcoz, J.; et al. Factors affecting cognitive outcome in early pediatric stroke. Neurol 2014, 82, 784–792. [Google Scholar] [CrossRef]
- Anderson, V.; Anderson, P.; Grimwood, K.; Nolan, T. Cognitive and Executive Function 12 Years after Childhood Bacterial Meningitis: Effect of Acute Neurologic Complications and Age of Onset. J. Pediatr. Psychol. 2004, 29, 67–81. [Google Scholar] [CrossRef] [PubMed]
- Zainel, A.; Mitchell, H.; Sadarangani, M. Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention. Microorganisms 2021, 9, 535. [Google Scholar] [CrossRef] [PubMed]
- Christie, D.; Rashid, H.; El-Bashir, H.; Sweeney, F.; Shore, T.; Booy, R.; Viner, R.M. Impact of meningitis on intelligence and development: A systematic review and meta-analysis. PLoS ONE 2017, 12, e0175024. [Google Scholar] [CrossRef] [PubMed]
- de Jonge, R.C.; van Furth, A.M.; Wassenaar, M.; Gemke, R.J.; Terwee, C.B. Predicting sequelae and death after bacterial meningitis in childhood: A systematic review of prognostic studies. BMC Infect. Dis. 2010, 10, 232. [Google Scholar] [CrossRef]
- Shieh, H.H.; Ragazzi, S.L.B.; Gilio, A.E. Risk factors for neurological complications and sequelae childhood acute bacterial meningitis. J. Pediatr. 2012, 88, 184. [Google Scholar] [CrossRef] [PubMed]
- Teixeira, D.C.; Diniz, L.M.O.; Guimarães, N.S.; Moreira, H.M.D.A.S.; Teixeira, C.C.; Romanelli, R.M.D.C. Risk factors associated with the outcomes of pediatric bacterial meningitis: A systematic review. J. De Pediatr. 2020, 96, 159–167. [Google Scholar] [CrossRef]
- Cullen, N.K.; Weisz, K. Cognitive correlates with functional outcomes after anoxic brain injury: A case-controlled comparison with traumatic brain injury. Brain Inj. 2011, 25, 35–43. [Google Scholar] [CrossRef]
- Howard, R.S.; Holmes, P.A.; Koutroumanidis, M.A. Hypoxic-ischaemic brain injury. Pract. Neurol. 2011, 11, 4–18. [Google Scholar] [CrossRef]
- Johnson, A.R.; DeMatt, E.; Salorio, C.F. Predictors of outcome following acquired brain injury in children. Dev. Disabil. Res. Rev. 2009, 15, 124–132. [Google Scholar] [CrossRef]
- Perez, A.; Ritter, S.; Brotschi, B.; Werner, H.; Caflisch, J.; Martin, E.; Latal, B. Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy. J. Pediatr. 2013, 163, 454–459. [Google Scholar] [CrossRef]
- Slomine, B.S.; Silverstein, F.S.; Christensen, J.R.; Page, K.; Holubkov, R.; Dean, J.M.; Moler, F.W. Neuropsychological outcomes of children 1 year after pediatric cardiac arrest: Secondary analysis of 2 randomized clinical trials. JAMA Neurol. 2018, 75, 1502–1510. [Google Scholar] [CrossRef] [PubMed]
- van Zellem, L.; Buysse, C.; Madderom, M.; Legerstee, J.S.; Aarsen, F.; Tibboel, D.; Utens, E.M. Long-term neuropsychological outcomes in children and adolescents after cardiac arrest. Intensive Care Med. 2015, 41, 1057–1066. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Anderson, C.A.; Arciniegas, D.B. Cognitive sequelae of hypoxic-ischemic brain injury: A review. Neurorehabilitation 2010, 26, 47–63. [Google Scholar] [CrossRef] [PubMed]
- Kirkwood, M.; Janusz, J.; Yeates, K.O.; Taylor, H.G.; Wade, S.L.; Stancin, T.; Drotar, D. Prevalence and correlates of depressive symptoms following traumatic brain injuries in children. Child Neuropsychol. 2000, 6, 195–208. [Google Scholar] [CrossRef] [PubMed]
- Max, J.E.; Wilde, E.A.; Bigler, E.D.; MacLeod, M.; Vasquez, A.C.; Schmidt, A.T.; Chapman, S.B.; Hotz, G.; Yang, T.T.; Levin, H.S. Psychiatric disorders after pediatric traumatic brain injury: A prospective, longitudinal, controlled study. J. Neuropsychiatry Clin. Neurosci. 2012, 24, 427–436. [Google Scholar] [CrossRef]
- Max, J.E.; Schachar, R.J.; Landis, J.; Bigler, E.D.; Wilde, E.A.; Saunders, A.E.; Ewing-Cobbs, L.; Chapman, S.B.; Dennis, M.; Hanten, G.; et al. Psychiatric disorders in children and adolescents in the first six months after mild traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 2013, 25, 187–197. [Google Scholar] [CrossRef]
- Lehman, L.L.; Maletsky, K.; Beaute, J.; Rakesh, K.; Kapur, K.; Rivkin, M.J.; Mrakotsky, C. Prevalence of symptoms of anxiety, depression, and post-traumatic stress disorder in parents and children following pediatric stroke. J. Child Neurol. 2020, 35, 472–479. [Google Scholar] [CrossRef]
- Davydow, D.S.; Richardson, L.P.; Zatzick, D.F.; Katon, W.J. Psychiatric morbidity in pediatric critical illness survivors: A comprehensive review of the literature. Arch. Pediatr. Adolesc. Med. 2010, 164, 377–385. [Google Scholar] [CrossRef]
- Emery, C.A.; Barlow, K.M.; Brooks, B.L.; Max, J.E.; Villavicencio-Requis, A.; Gnanakumar, V.; Robertson, H.L.; Schneider, K.; Yeates, K.O. A systematic review of psychiatric, psychological, and behavioural outcomes following mild traumatic brain injury in children and adolescents. Can. J. Psychiatry 2016, 61, 259–269. [Google Scholar] [CrossRef]
- Small, L.; Melnyk, B.M. Early predictors of post-hospital adjustment problems in critically Ill young children. Res. Nurs. Health 2006, 29, 622–635. [Google Scholar] [CrossRef]
- Connolly, D.; McClowry, S.; Hayman, L.; Mahony, L.; Artman, M. Posttraumatic stress disorder in children after cardiac surgery. J. Pediatr. 2004, 144, 480–484. [Google Scholar] [CrossRef]
- Colville, G.; Kerry, S.; Pierce, C. Children’s factual and delusional memories of intensive care. Am. J. Respir. Crit. Care Med. 2008, 177, 976–982. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Nelson, L.P.; Lachman, S.E.; Li, S.W.; Gold, J.I. The Effects of Family Functioning on the Development of Posttraumatic Stress in Children and their Parents following Admission to the Pediatric Intensive Care Unit. Pediatr. Crit. Care Med. 2019, 20, e208. [Google Scholar] [CrossRef] [PubMed]
- Schachar, R.J.; Park, L.S.; Dennis, M. Mental health implications of traumatic brain injury (TBI) in children and youth. J. Can. Acad. Child Adolesc. Psychiatry 2015, 24, 100–108. [Google Scholar]
- Max, J.E.; Robertson, B.A.M.; Lansing, A.E. The phenomenology of personality change due to traumatic brain injury in children and adolescents. J. Neuropsychiatry Clin. Neurosci. 2001, 13, 161–170. [Google Scholar] [CrossRef] [PubMed]
- Greenham, M.; Anderson, V.; Hearps, S.; Ditchfield, M.; Coleman, L.; Mackay, M.T.; Monagle, P.; Gordon, A.L. Psychosocial function in the first year after childhood stroke. Dev. Med. Child Neurol. 2017, 59, 1027–1033. [Google Scholar] [CrossRef] [PubMed]
- Gerring, J.P.; Slomine, B.; Vasa, R.A.; Grados, M.; Chen, A.; Rising, W.; Christensen, J.R.; Denckla, M.B.; Ernst, M. Clinical predictors of posttraumatic stress disorder after closed head injury in children. J. Am. Acad. Child Adolesc. Psychiatry 2002, 41, 157–165. [Google Scholar] [CrossRef]
- Judge, D.; Nadel, S.; Vergnaud, S.; Garralda, E.M. Psychiatric adjustment following meningococcal disease treated on a PICU. J. Intensive Care Med. 2002, 28, 648–650. [Google Scholar] [CrossRef]
- Shears, D.; Nadel, S.; Gledhill, J.; Garralda, M.E. Short-term psychiatric adjustment of children and their parents following meningococcal disease. Pediatr. Crit. Care Med. 2005, 6, 39–43. [Google Scholar] [CrossRef]
- Truss, K.; Godfrey, C.; Takagi, M.; Babl, F.E.; Bressan, S.; Hearps, S.; Clarke, C.; Dunne, K.; Anderson, V. Trajectories and risk factors for post-traumatic stress symptoms following pediatric concussion. J. Neurotrauma 2017, 34, 2272–2279. [Google Scholar] [CrossRef]
- Merikangas, K.R.; He, J.P.; Burstein, M.; Swanson, S.A.; Avenevoli, S.; Cui, L.; Benjet, C.; Georgiades, K.; Swendsen, J. Lifetime prevalence of mental disorders in US adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A). J. Am. Acad. Child Adolesc. Psychiatry 2010, 49, 980–989. [Google Scholar] [CrossRef] [PubMed]
- Hawley, C.A. Reported problems and their resolution following mild, moderate and severe traumatic brain injury amongst children and adolescents in the UK. Brain Inj. 2003, 17, 105–129. [Google Scholar] [CrossRef] [PubMed]
- Kirkwood, M.W.; Yeates, K.O.; Taylor, H.G.; Randolph, C.; McCrea, M.; Anderson, V.A. Management of pediatric mild traumatic brain injury: A neuropsychological review from injury through recovery. J. Clin. Neuropsychol. 2008, 22, 769–800. [Google Scholar] [CrossRef] [PubMed]
- Max, J.E.; Keatley, E.; Wilde, E.A.; Bigler, E.D.; Levin, H.S.; Schachar, R.J.; Saunders, A.; Ewing-Cobbs, L.; Chapman, S.B.; Dennis, M.; et al. Anxiety disorders in children and adolescents in the first six months after traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 2011, 23, 29–39. [Google Scholar] [CrossRef]
- Max, J.E.; Keatley, E.; Wilde, E.A.; Bigler, E.D.; Schachar, R.J.; Saunders, A.E.; Ewing-Cobbs, L.; Chapman, S.B.; Dennis, M.; Yang, T.T.; et al. Depression in children and adolescents in the first 6 months after traumatic brain injury. Int. J. Dev. Neurosci. 2012, 30, 239–245. [Google Scholar] [CrossRef]
- Durish, C.L.; Pereverseff, R.S.; Yeates, K.O. Depression and depressive symptoms in pediatric traumatic brain injury: A scoping review. J. Head Trauma Rehabil. 2018, 33, E18. [Google Scholar] [CrossRef]
- McKinlay, A.; Grace, R.; Horwood, J.; Fergusson, D.; MacFarlane, M. Adolescent psychiatric symptoms following preschool childhood mild traumatic brain injury: Evidence from a birth cohort. J. Head Trauma Rehabil. 2009, 24, 221–227. [Google Scholar] [CrossRef]
- Max, J.E.; Mathews, K.; Lansing, A.E.; Robertson, B.A.; Fox, P.T.; Lancaster, J.L.; Manes, F.F.; Smith, J. Psychiatric disorders after childhood stroke. J. Am. Acad. Child Adolesc. Psychiatry 2002, 41, 555–562. [Google Scholar] [CrossRef]
- Bozzola, E.; Bergonzini, P.; Bozzola, M.; Tozzi, A.E.; Masci, M.; Rossetti, C.; Carloni, E.; Villani, A. Neuropsychological and internalizing problems in acute central nervous system infections: A 1-year follow-up. Ital. J. Pediatr. 2017, 43, 96. [Google Scholar] [CrossRef] [PubMed]
- Bozzola, E.; Spina, G.; Bergonzini, P.; Bozzola, M.; Raponi, M.; Villani, A. Anxiety disorders in acute central nervous system infections. Ital. J. Pediatr. 2020, 46, 23. [Google Scholar]
- Anderson, V.; Gomes, A.; Greenham, M.; Hearps, S.; Gordon, A.; Rinehart, N.; Gonzalez, L.; Yeates, K.O.; Hajek, C.A.; Lo, W.; et al. Social competence following pediatric stroke: Contributions of brain insult and family environment. Soc. Neurosci. 2014, 9, 471–483. [Google Scholar] [CrossRef] [PubMed]
- Greenham, M.; Hearps, S.; Gomes, A.; Rinehart, N.; Gonzalez, L.; Gordon, A.; Mackay, M.; Lo, W.; Yeates, K.; Anderson, V. Environmental contributions to social and mental health outcomes following pediatric stroke. Dev. Neuropsychol. 2015, 40, 348–362. [Google Scholar] [CrossRef] [PubMed]
- Gordon, A.L.; Ganesan, V.; Towell, A.; Kirkham, F.J. Functional outcome following stroke in children. J. Child Neurol. 2002, 17, 429–434. [Google Scholar] [CrossRef] [PubMed]
- Hurvitz, E.; Warschausky, S.; Berg, M.; Tsai, S. Long-term functional outcome of pediatric stroke survivors. Top. Stroke Rehabil. 2004, 11, 51–59. [Google Scholar] [CrossRef]
- Shultz, E.L.; Hoskinson, K.R.; Keim, M.C.; Dennis, M.; Taylor, H.G.; Bigler, E.D.; Shultz, E.L.; Hoskinson, K.R.; Keim, M.C.; Dennis, M.; et al. Adaptive functioning following pediatric traumatic brain injury: Relationship to executive function and processing speed. Neuropsychology 2016, 30, 830. [Google Scholar] [CrossRef]
- Catroppa, C.; Crossley, L.; Hearps, S.J.; Yeates, K.O.; Beauchamp, M.; Rogers, K.; Anderson, V. Social and behavioral outcomes: Pre-injury to six months following childhood traumatic brain injury. J. Neurotrauma 2015, 32, 109–115. [Google Scholar] [CrossRef]
- Everts, R.; Pavlovic, J.; Kaufmann, F.; Uhlenberg, B.; Seidel, U.; Nedeltchev, K.; Perrig, W.; Steinlin, M. Cognitive functioning, behavior, and quality of life after stroke in childhood. Child Neuropsychol. 2008, 14, 323–338. [Google Scholar] [CrossRef] [PubMed]
- Steinlin, M.; Roellin, K.; Schroth, G. Long-term follow-up after stroke in childhood. Eur. J. Pediatr. 2004, 163, 245–250. [Google Scholar] [CrossRef] [PubMed]
- Dennis, M.; Agostino, A.; Taylor, H.G.; Bigler, E.D.; Rubin, K.; Vannatta, K.; Gerhardt, C.A.; Stancin, T.; Yeates, K.O. Emotional expression and socially modulated emotive communication in children with traumatic brain injury. J. Int. Neuropsychol. Soc. 2013, 19, 34–43. [Google Scholar] [CrossRef]
- Dennis, M.; Simic, N.; Bigler, E.D.; Abildskov, T.; Agostino, A.; Taylor, H.G.; Rubin, K.; Vannatta, K.; Gerhardt, C.A.; Stancin, T.; et al. Cognitive, affective, and conative theory of mind (ToM) in children with traumatic brain injury. Dev. Cogn. Neurosci. 2013, 5, 25–39. [Google Scholar] [CrossRef]
- De Schryver, E.L.; Kappelle, L.J.; Jennekens-Schinkel, A.; Peters, A.B. Prognosis of ischemic stroke in childhood: A long-term follow-up study. Dev. Med. Child Neurol. 2000, 42, 313–318. [Google Scholar] [CrossRef]
- Neuner, B.; von Mackensen, S.; Krümpel, A.; Manner, D.; Friefeld, S.; Nixdorf, S.; Frühwald, M.; deVeber, G.; Nowak-Göttl, U. Health-related quality of life in children and adolescents with stroke, self-reports, and parent/proxies reports: Cross-sectional investigation. Ann. Neurol. 2011, 70, 70–78. [Google Scholar] [CrossRef] [PubMed]
- O’Keeffe, F.; Stark, D.; Murphy, O.; Ganesan, V.; King, J.; Murphy, T. Psychosocial outcome and quality of life following childhood stroke–A systematic review. Dev. Neurorehabilit. 2017, 20, 428–442. [Google Scholar] [CrossRef] [PubMed]
- Schwartz, L.; Taylor, H.G.; Drotar, D.; Yeates, K.O.; Wade, S.L.; Stancin, T. Long-term behavior problems following pediatric traumatic brain injury: Prevalence, predictors, and correlates. J. Pediatr. Psychol. 2003, 28, 251–263. [Google Scholar] [CrossRef] [PubMed]
- Yeates, K.O.; Gerhardt, C.A.; Bigler, E.D.; Abildskov, T.; Dennis, M.; Rubin, K.H.; Stancin, T.; Taylor, H.G.; Vannatta, K. Peer relationships of children with traumatic brain injury. J. Int. Neuropsychol. 2013, 19, 518–527. [Google Scholar] [CrossRef] [PubMed]
- Saha, S.K.; Khan, N.Z.; Ahmed, A.N.U.; Ruhul Amin, M.; Hanif, M.; Mahbub, M.; Anwar, K.S.; Qazi, S.A.; Kilgore, P.; Baqui, A.H.; et al. Neurodevelopmental sequelae in pneumococcal meningitis cases in Bangladesh: A comprehensive follow-up study. Clin. Infect. Dis. 2009, 48, S90–S96. [Google Scholar] [CrossRef]
- Câmara-Costa, H.; Opatowski, M.; Francillette, L.; Toure, H.; Brugel, D.; Laurent-Vannier, A.; Meyer, P.; Watier, L.; Dellatolas, G.; Chevignard, M. Self-and parent-reported Quality of Life 7 years after severe childhood traumatic brain injury in the Traumatisme Grave de l’Enfant cohort: Associations with objective and subjective factors and outcomes. Qual. Life Res. 2020, 29, 515–528. [Google Scholar] [CrossRef]
- Logar, M.; Arnez, M.; Kolbl, J.; Avsic-Zupanc, T.; Strle, F. Comparison of the epidemiological and clinical features of tick- borne encephalitis in children and adults. Infection 2000, 28, 74–77. [Google Scholar] [CrossRef]
- Maaijwee, N.A.; Arntz, R.M.; Rutten-Jacobs, L.C.; Schaapsmeerders, P.; Schoonderwaldt, H.C.; van Dijk, E.J.; de Leeuw, F.E. Post-stroke fatigue and its association with poor functional outcome after stroke in young adults. J. Neurol. Neurosurg. Psychiatry 2015, 86, 1120–1126. [Google Scholar] [CrossRef]
- Macartney, G.; Harrison, M.B.; VanDenKerkhof, E.; Stacey, D.; Carthy, M. Quality of life and symptoms in pediatric brain tumor survivors: A systematic review. J. Pediatr. Oncol. Nurs. 2014, 31, 65–77. [Google Scholar] [CrossRef]
- Riccardi, J.S.; Ciccia, A. Cognitive fatigue in pediatric traumatic brain injury: A meta-analysis and scoping review. J. Head Trauma Rehabil. 2021, 36, 226–241. [Google Scholar] [CrossRef] [PubMed]
- Sumpter, R.; Brunklaus, A.; McWilliam, R.; Dorris, L. Health-related quality-of-life and behavioural outcome in survivors of childhood meningitis. Brain Inj. 2011, 25, 1288–1295. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, L.F.; Sahni, A.S.; Attarian, H. Sleep disorders in traumatic brain injury. Neurorehabilitation 2018, 43, 257–266. [Google Scholar] [CrossRef]
- Russell, K.; Hutchison, M.G.; Selci, E.; Leiter, J.; Chateau, D.; Ellis, M.J. Academic outcomes in high-school students after a concussion: A retrospective population-based analysis. PLoS ONE 2016, 11, e0165116. [Google Scholar]
- Jackson, D.B.; Testa, A.; Vaughn, M.G. Traumatic Brain Injury and School Readiness among Preschool-Aged Children in the United States. Pediatr. Neurol. 2021, 116, 2–6. [Google Scholar] [CrossRef] [PubMed]
- Barnes, M.A.; Dennis, M.; Wilkinson, M. Reading after closed head injury in childhood: Effects on accuracy, fluency, and comprehension. Dev. Neuropsychol. 1999, 15, 1–24. [Google Scholar] [CrossRef]
- Berger-Gross, P.; Shackelford, M. Closed-head injury in children: Neuropsychological and scholastic outcomes. Percept. Mot. Skills 1985, 61, 254E. [Google Scholar] [CrossRef]
- Rodrigues, S.D.D.; Ciasca, S.M.; Guimarães, I.E.; Elias, K.M.I.D.F.; Oliveira, C.C.; Moura-Ribeiro, M.V.L.D. Does Stroke Impair Learning in Children? Stroke Res. Treat. 2011, 2011, 369836. [Google Scholar] [CrossRef]
- Allman, C.; Scott, R.B. Neuropsychological sequelae following pediatric stroke: A nonlinear model of age at lesion effects. Child Neuropsychol. 2013, 19, 97–107. [Google Scholar] [CrossRef]
- Max, J.E.; Bruce, M.; Keatley, E.; Delis, D. Pediatric Stroke: Plasticity, Vulnerability, and Age of Lesion Onset. J. Neuropsychiatry Clin. Neurosci. 2010, 22, 30–39. [Google Scholar] [CrossRef]
- Jacomb, I.; Porter, M.; Brunsdon, R.; Mandalis, A.; Parry, L. Cognitive outcomes of pediatric stroke. Child Neuropsychol. 2016, 24, 287–303. [Google Scholar] [CrossRef] [PubMed]
- Grimwood, K. Twelve year outcomes following bacterial meningitis: Further evidence for persisting effects. Arch. Dis. Child. 2000, 83, 111–116. [Google Scholar] [CrossRef] [PubMed]
- Thaler, N.S.; Reger, S.L.; Ringdahl, E.N.; Mayfield, J.W.; Goldstein, G.; Allen, D.N. Neuropsychological profiles of six children with anoxic brain injury. Child Neuropsychol. 2013, 19, 479–494. [Google Scholar] [CrossRef] [PubMed]
- Shaklai, S.; Fish, R.P.; Simantov, M.; Groswasser, Z. Prognostic factors in childhood-acquired brain injury. Brain Inj. 2018, 32, 533–539. [Google Scholar] [CrossRef] [PubMed]
- Kingery, K.M.; Narad, M.E.; Taylor, H.G.; Yeates, K.O.; Stancin, T.; Wade, S.L. Do Children Who Sustain Traumatic Brain Injury in Early Childhood Need and Receive Academic Services 7 Years After Injury? J. Dev. Behav. Pediatr. 2017, 38, 728–735. [Google Scholar] [CrossRef]
- Lowry, R.; Haarbauer-Krupa, J.K.; Breiding, M.J.; Thigpen, S.; Rasberry, C.N.; Lee, S.M. Concussion and Academic Impairment among U.S. High School Students. Am. J. Prev. Med. 2019, 57, 733–740. [Google Scholar] [CrossRef] [PubMed]
- Anderson, V.; Brown, S.; Newitt, H.; Hoile, H. Long-term outcome from childhood traumatic brain injury: Intellectual ability, personality, and quality of life. Neuropsychology 2011, 25, 176–184. [Google Scholar] [CrossRef]
- de Louvois, J.; Halket, S.; Harvey, D. Effect of meningitis in infancy on school-leaving examination results. Arch. Dis. Child. 2007, 92, 959–962. [Google Scholar] [CrossRef]
- Koomen, I.; Grobbee, D.E.; Jennekens-Schinkel, A.; Roord, J.J.; Van Furth, A.M. Parental perception of educational, behavioural and general health problems in school-age survivors of bacterial meningitis. Acta Paediatr. 2003, 92, 177–185. [Google Scholar] [CrossRef]
- Glang, A.; Todis, B.; Thomas, C.W.; Hood, D.; Bedell, G.; Cockrell, J. Return to school following childhood TBI: Who gets services? Neurorehabilitation 2008, 23, 477–486. [Google Scholar] [CrossRef]
- Vassel-Hitier, J.; Verdier, V.; Rasquier, S.; Chalard, A.; Laurent-Vannier, A.; Chevignard, M. Language, intellectual and educational outcomes after moderate-to-severe traumatic brain injury sustained before the age of 18 months. Brain Inj. 2019, 33, 1105–1115. [Google Scholar] [CrossRef]
- Christerson, S.; Strömberg, B. Stroke in Swedish children II: Long-term outcome. Acta Paediatr. 2010, 99, 1650–1656. [Google Scholar] [CrossRef] [PubMed]
- Ganesan, V.; Hogan, A.; Shack, N.; Gordon, A.; Isaacs, E.; Kirkham, F.J. Outcome after ischaemic stroke in childhood. Dev. Med. Child Neurol. 2000, 42, 455–461. [Google Scholar] [CrossRef]
- Treble-Barna, A.; Zang, H.; Zhang, N.; Taylor, H.G.; Yeates, K.O.; Wade, S. Long-Term Neuropsychological Profiles and Their Role as Mediators of Adaptive Functioning after Traumatic Brain Injury in Early Childhood. J. Neurotrauma 2017, 34, 353–362. [Google Scholar] [CrossRef] [PubMed]
- Wasserman, E.B.; Bazarian, J.J.; Mapstone, M.; Block, R.; van Wijngaarden, E. Academic Dysfunction After a Concussion Among US High School and College Students. Am. J. Public Health 2016, 106, 1247–1253. [Google Scholar] [CrossRef] [PubMed]
- Rozbacher, A.; Selci, E.; Leiter, J.; Ellis, M.; Russell, K. The Effect of Concussion or Mild Traumatic Brain Injury on School Grades, National Examination Scores, and School Attendance: A Systematic Review. J. Neurotrauma 2017, 34, 2195–2203. [Google Scholar] [CrossRef] [PubMed]
- Kinsella, G.J.; Prior, M.; Sawyer, M.; Ong, B.; Murtagh, D.; Eisenmajer, R.; Bryan, D.; Anderson, V.; Klug, G. Predictors and indicators of academic outcome in children 2 years following traumatic brain injury. J. Int. Neuropsychol. Soc. 1997, 3, 608–616. [Google Scholar] [CrossRef]
- Robertson, C.; Finer, N.; Grace, M. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J. Pediatr. 1989, 114, 753–760. [Google Scholar] [CrossRef]
- Catroppa, C.; Anderson, V. Recovery in Memory Function, and its Relationship to Academic Success, at 24 Months Following Pediatric TBI. Child Neuropsychol. 2007, 13, 240–261. [Google Scholar] [CrossRef]
- Arroyos-Jurado, E.; Paulsen, J.S.; Merrell, K.W.; Lindgren, S.D.; Max, J.E. Traumatic Brain Injury in School-Age Children Academic and Social Outcome. J. Sch. Psychol. 2000, 38, 571–587. [Google Scholar] [CrossRef]
- Martin, A.K.; Petersen, A.J.; Sesma, H.W.; Koolmo, M.B.; Ingram, K.M.; Slifko, K.B.; Nguyen, V.N.; Doss, R.C.; Linabery, A.M. Learning and Attention Deficit/Hyperactivity Disorders as Risk Factors for Prolonged Concussion Recovery in Children and Adolescents. J. Int. Neuropsychol. Soc. 2021, 28, 109–122. [Google Scholar] [CrossRef] [PubMed]
- Zirkel, P.A. Special education law: Illustrative basics and nuances of key IDEA components. J. Teach. Educ. 2015, 38, 263–275. [Google Scholar] [CrossRef]
- Richards, D.M. The Top Section 504 Errors: Expert Guidance to Avoid Common Compliance Mistakes; LPR: New York, NY, USA, 2021. [Google Scholar]
- Yell, M.L. Endrew F. v. Douglas County School District (2017): Implications for educating students with emotional and behavioral disorders. J. Emot. Behav. Disord. 2019, 45, 53–62. [Google Scholar] [CrossRef]
- Bjorn, P.M.; Aro, M.T.; Koponen, T.K.; Fuchs, L.S.; Fuchs, D.H. The many faces of special education within RTI frameworks in the United States and Finland. Learn. Disabil. Q. 2015, 39, 58–66. [Google Scholar] [CrossRef]
- Baker, J.M.; Zigmond, N. The Meaning and Practice of Inclusion for Students with Learning Disabilities. J. Spec. Educ. 1995, 29, 163–180. [Google Scholar] [CrossRef]
- Archer, A.L.; Hughes, C.A. Explicit Instruction: Effective and Efficient Teaching; The Guilford Press: New York, NY, USA, 2011. [Google Scholar]
- Canto, A.I.; Crisp, M.A.; Larach, H.; Blankenship, A.P. Inclusion and Students with Traumatic Brain Injuries. In General and Special Education Inclusion in an Age of Change: Impact on Students with Disabilities; Emerald Group Publishing Limited: Bradford, UK, 2016; pp. 157–177. [Google Scholar]
- Hallahan, D.P.; Kauffman, J.M.; Pullen, P.C. Exceptional Learners: An Introduction to Special Education, 12th ed.; Pearson: London, UK, 2012. [Google Scholar]
- Fuchs, L.S.; Mock, D.; Morgan, P.L.; Young, C.L. Responsiveness-to-intervention: Definition, evidence, and implications the learning disabilities construct. J. Learn. Disabil. 2003, 18, 157–171. [Google Scholar] [CrossRef]
- Kavale, K.A.; Kauffman, J.M.; Bachmeier, R.J.; LeFever, G.B. Response to intervention: Separating the rhetoric of self-congratulation from the reality of specific learning disability identification. Learn. Disabil. Q. 2008, 31, 135–150. [Google Scholar] [CrossRef]
- Hallahan, D.P.; Lloyd, J.W.; Kauffman, J.M.; Weiss, M.; Martinez, E. Introduction to Learning Disabilities, 3rd ed.; Pearson: London, UK, 2005. [Google Scholar]
- Chesire, D.J.; Canto, A.I.; Buckley, V.A. Hospital–school collaboration to serve the needs of children with traumatic brain injury. J. Appl. Psychol. 2011, 27, 60–76. [Google Scholar] [CrossRef]
- Canto, A.I.; Chesire, D.J.; Buckley, V.A.; Andrews, T.W.; Roehrig, A.D. Barriers to meeting the needs of students with traumatic brain injury. J. Educ. Psychol. 2014, 30, 88–103. [Google Scholar] [CrossRef]
- Jantz, P.B.; Davies, S.C.; Bigler, E.D. Working with Traumatic Brain Injury in Schools: Transition, Assessment, and Intervention (School-Based Practice in Action), 1st ed.; Routledge: Abingdon, OX, USA, 2014. [Google Scholar]
- Vroland-Nordstrand, K.; Eliasson, A.C.; Jacobsson, H.; Johansson, U.; Krumlinde-Sundholm, L. Can children identify and achieve goals for intervention? A randomized trial comparing two goal-setting approaches. Dev. Med. Child Neurol. 2016, 58, 589–596. [Google Scholar] [CrossRef]
- Arndt, S.A.; Konrad, M.; Test, D.W. Effects of the self-directed IEP on student participation in planning meetings. Remedial Spec. Educ. 2006, 27, 194–207. [Google Scholar] [CrossRef]
- Danneker, J.E.; Bottge, B.A. Benefits of and barriers to elementary student-led individualized education programs. Remedial Spec. Educ. 2009, 30, 225–233. [Google Scholar] [CrossRef]
- Cameto, R.; Levine, P.; Wagner, M. Transition Planning for Students with Disabilities: A Special Topic Report of Findings from the National Longitudinal Transition Study-2 (NLTS2). Natl. Cent. Spec. Educ. Res. 2004. Available online: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://files.eric.ed.gov/fulltext/ED496547.pdf (accessed on 1 August 2022).
- Shogren, K.A.; Plotner, A.J. Transition planning for students with intellectual disability, autism, or other disabilities: Data from the National Longitudinal Transition Study-2. Intellect. Dev. Disabil. 2012, 50, 16–30. [Google Scholar] [CrossRef]
- Hallahan, D.P.; Cohen, S.B. Many students with learning disabilities are not receiving special education. J. Learn. Disabil. 2008, 15, 3–10. [Google Scholar]
- Gilmour, A.F. Has inclusion gone too far? Weighing its effects on students with disabilities, their peers, and teachers. Educ. Next 2018, 18, 8–16. [Google Scholar]
- Kauffman, J.M.; Felder, M.; Ahrbeck, B.; Badar, J.; Schneiders, K. Inclusion of all students in general education? International appeal to a more temperate approach to inclusion. J. Int. Spec. Needs Educ. 2018, 21, 1–10. [Google Scholar]
- Mock, D.R.; Kauffman, J.M. Preparing teachers for full inclusion. Is it possible? Teach. Educ. 2002, 37, 202–215. [Google Scholar] [CrossRef]
- Davidson, D.N.; Algozzine, B. Administrators’ perceptions of special education law. J. Spec. Educ. Leadersh. 2002, 15, 43–48. [Google Scholar]
- Sun, A.Q.; Xin, J.F. School principals’ opinions about special education services. Prev. Sch. Fail. 2020, 64, 106–115. [Google Scholar] [CrossRef]
- Beausaert, S.; Froehlich, D.E.; Devos, C.; Riley, P. Effects of support on stress and burnout in school principals. Educ. Res. 2016, 58, 347–365. [Google Scholar] [CrossRef]
- Billingsley, B.; Bettini, E. Special education teacher attrition and retention: A review of the literature. Rev. Educ. Res. 2019, 89, 697–744. [Google Scholar] [CrossRef]
- Carter, S.J. Burnout among special education administrators: A preliminary study. J. Spec. Educ. Leadersh. 2011, 24, 104–110. [Google Scholar]
- Hinds, E.; Backen Jones, L.; Gau, J.M.; Forrester, K.K.; Biglan, A. Teacher distress and the role of experiential avoidance. Psychol. Sch. 2015, 52, 284–297. [Google Scholar] [CrossRef] [PubMed]
- Davies, S.C.; Fox, E.F.; Glang, A.; Ettel, D.; Thomas, C. Traumatic brain injury and teacher training: A gap in educator preparation. J. Dev. Phys. Disabil. 2013, 32, 55–65. [Google Scholar]
- Ettel, D.; Glang, A.E.; Todis, B.; Davies, S.C. Traumatic brain injury: Persistent misconceptions and knowledge gaps among educators. Except. Educ. Int. 2016, 26, 1–18. [Google Scholar]
- Hooper, S.R. Myths and misconceptions about traumatic brain injury: Endorsements by school psychologists. Exceptionality 2006, 14, 171–182. [Google Scholar] [CrossRef]
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Vanderlind, W.M.; Demers, L.A.; Engelson, G.; Fowler, R.C.; McCart, M. Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury. Children 2022, 9, 1321. https://0-doi-org.brum.beds.ac.uk/10.3390/children9091321
Vanderlind WM, Demers LA, Engelson G, Fowler RC, McCart M. Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury. Children. 2022; 9(9):1321. https://0-doi-org.brum.beds.ac.uk/10.3390/children9091321
Chicago/Turabian StyleVanderlind, W. Michael, Lauren A. Demers, Georgina Engelson, Rollen C. Fowler, and Melissa McCart. 2022. "Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury" Children 9, no. 9: 1321. https://0-doi-org.brum.beds.ac.uk/10.3390/children9091321