Vitamin D and Subclinical Cardiovascular Damage in Essential Hypertension
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Populations
2.2. Blood Pressure Measurements
2.3. Laboratory Determinations
2.4. Echocardiographic Measurements
2.5. Central BP and Pulse Wave Reflection Measurements
2.6. Statistical Analysis
2.7. Ethical Approval
3. Results
3.1. Study Population
3.2. Correlational Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Conflicts of Interest
References
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All | Vitamin D < 20 ng/mL | Vitamin D 20–30 ng/mL | Vitamin D > 30 ng/mL | p-Value | |
---|---|---|---|---|---|
(n = 500) | (n = 219) | (n = 85) | (n = 196) | ||
Gender, M/F | 267/233 | 121/98 | 47/38 | 99/97 | 0.453 * |
Age, years | 54.7 ± 10.9 | 57 ± 10.4 | 55.8 ± 12.5 | 51.5 ± 9.9 | <0.0002 |
BMI, Kg/m2 | 28.7 ± 4.8 | 29.7 ± 4.9 | 28.1 ± 4.3 | 27.7 ± 4.8 | <0.0001 |
SBP, mmHg | 144.0 ± 14 | 145.6 ± 15.9 | 142.4 ± 13 | 142.8 ± 12.1 | 0.071 |
DBP, mmHg | 90.5 ± 7.0 | 90.4 ± 7.6 | 90 ± 6.4 | 90.9 ± 6.4 | 0.58 |
PP, mmHg | 53.4 ± 15.4 | 55.1 ± 16.4 | 52.4 ± 16.4 | 51.9 ± 13.6 | 0.083 |
Matsuda Index | 68.8 ± 40.5 | 53 ± 31.1 | 70.7 ± 36.6 | 88.4 ± 43.4 | <0.0001 |
Glucose, mg/dL | 94.2 ± 9.0 | 96.3 ± 8.9 | 94.1 ± 7.4 | 91.9 ± 9.2 | <0.0001 |
Insulin, mU/L | 13.1 ± 5.9 | 15.1 ± 6.1 | 12.2 ± 6 | 11.2 ± 4.8 | <0.0001 |
Serum LDL, mg/dL | 134.8 ± 35.3 | 137.9 ± 36 | 131.4 ± 35.5 | 132.9 ± 34.2 | 0.207 |
Serum hdl, mg/dL | 51.5 ± 13.9 | 50 ± 13.3 | 55.1 ± 14.4 | 51.6 ± 14.2 | 0.015 |
Serum Triglycerides, mg/dL | 127.2 ± 54.4 | 135.1 ± 59 | 127.5 ± 55.4 | 118 ± 46.9 | 0.006 |
e-GFR, mL/min/1.73 m2 | 96.6 ± 22.7 | 93.1 ± 22.4 | 92.9 ± 23.4 | 102.4 ± 21.6 | <0.0001 |
PTH, pg/ml | 59.4 ± 37.0 | 75.5 ± 37.2 | 51.4 ± 33.4 | 44.27 ± 30.6 | <0.0001 |
Calcium, mg/dL | 9.5 ± 0.5 | 9.5 ± 0.6 | 9.5 ± 0.4 | 9.5 ± 0.4 | 0.862 |
Phosphorus, mg/dL | 3.3 ± 0.5 | 3.2 ± 0.5 | 3.2 ± 0.4 | 3.3 ± 0.5 | 0.520 |
hs-CRP, mg/L | 2.6 ± 1.9 | 2.7 ± 2.0 | 2.6 ± 2.0 | 2.4 ± 1.8 | 0.099 |
Smokers, n (%) | 122 (24.4) | 51 (23.3) | 17 (20) | 55 (26.6) | 0.295 * |
LVMI, g/m2 | 115.3 ± 39.0 | 128.1 ± 39.0 | 110.7 ± 40.3 | 102.8 ± 33.9 | <0.0001 |
PWV, m/s | 6.9 ± 2.4 | 8.1 ± 2.7 | 6.4 ± 1.5 | 5.7 ± 1.4 | <0.0001 |
PWV | LVMI | |||
---|---|---|---|---|
R | p | R | p | |
log25(OH)D | −0.532 | <0.0001 | −0.437 | <0.0001 |
Matsuda Index | −0.468 | <0.0001 | −0.390 | <0.0001 |
Age, years | 0.280 | <0.0001 | 0.141 | 0.001 |
PP, mmHg | 0.116 | 0.005 | 0.231 | <0.0001 |
hs-CRP, mg/dl | 0.112 | 0.006 | 0.229 | <0.0001 |
Serum LDL, mg/dl | 0.188 | <0.0001 | 0.004 | 0.462 |
e-GFR, ml/min/1.73 m2 | −0.113 | 0.006 | −0.164 | <0.0001 |
BMI, Kg/m2 | 0.144 | 0.001 | 0.060 | 0.09 |
PWV | LVMI | |||
---|---|---|---|---|
Partial R2 (%) | p | Partial R2 (%) | p | |
log25(OH)D | 28.3 | <0.0001 | 19.1 | <0.0001 |
Matsuda Index | 6.8 | <0.0001 | 4.9 | <0.0001 |
Age, years | 2.7 | <0.0001 | - | - |
Serum LDL, mg/dl | 3.0 | 0.001 | - | - |
Smokers, yes/no | 0.8 | 0.010 | - | - |
PP, mmHg | - | - | 3.0 | <0.0001 |
hs-CRP, mg/dl | - | - | 2.2 | <0.0001 |
Total R2 (%) | 41.6 | 29.2 |
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Magurno, M.; Crescibene, D.; Spinali, M.; Cassano, V.; Armentaro, G.; Barbara, K.; Miceli, S.; Hribal, M.L.; Perticone, M.; Sciacqua, A. Vitamin D and Subclinical Cardiovascular Damage in Essential Hypertension. Endocrines 2021, 2, 133-141. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2020013
Magurno M, Crescibene D, Spinali M, Cassano V, Armentaro G, Barbara K, Miceli S, Hribal ML, Perticone M, Sciacqua A. Vitamin D and Subclinical Cardiovascular Damage in Essential Hypertension. Endocrines. 2021; 2(2):133-141. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2020013
Chicago/Turabian StyleMagurno, Marcello, Daniele Crescibene, Martina Spinali, Velia Cassano, Giuseppe Armentaro, Keti Barbara, Sofia Miceli, Marta L. Hribal, Maria Perticone, and Angela Sciacqua. 2021. "Vitamin D and Subclinical Cardiovascular Damage in Essential Hypertension" Endocrines 2, no. 2: 133-141. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2020013