Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers
Abstract
:1. Introduction
Aims of the Study
2. Materials and Methods
2.1. Definition of Healthcare Worker
2.2. Definition of COVID-19 Case
2.3. Pre-Existing Medical Conditions, Fitness to Work, and Vaccination
2.4. Acute Symptoms and Post-COVID-19 Symptoms
2.5. Medical Examination and Collection of Data
2.6. Statistical Analysis
3. Results
3.1. Baseline Characteristics of the Sample and the Acute Form of Infection
3.2. Post-COVID-19 Symptoms
3.3. Correlation between Most Common Post-COVID-19 Symptoms (Dyspnoea, Fatigue, and Musculoskeletal Pain) and Sample Characteristics
3.4. Multivariate Analysis for Post-COVID-19 Symptoms
4. Discussion
4.1. Limitations and Strengths
4.2. Practical Implications
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total Sample | Age (Mean ± SD) | p Value | Men (n,%) | Women (n, %) | p Value | |
---|---|---|---|---|---|---|
Asymptomatic | 0.031 * | 0.173 | ||||
Yes | 136 (42.1) | 43.1 (12.3) | 51 (48.1) | 85 (40.1) | ||
No | 182 (56.3) | 46.2 (11.6) | 55 (51.9) | 127 (59.9) | ||
Cough | 0.660 | 0.582 | ||||
Yes | 29 (9.1) | 46 (11.6) | 11 (10.4) | 18 (8.5) | ||
No | 289 (90.9) | 45 (12) | 95 (89.6) | 194 (91.5) | ||
Dyspnea | 0.030 * | 0.482 | ||||
Yes | 42 (13.2) | 48.8 (12) | 12 (11.3) | 30 (14.2) | ||
No | 276 (86.8) | 44.5 (11.8) | 94 (88.7) | 182 (85.8) | ||
Fatigue | 0.011 * | 0.203 | ||||
Yes | 102 (32.1) | 47.6 (11.2) | 29 (27.4) | 73 (34.4) | ||
No | 216 (67.9) | 43.9 (12.1) | 77 (72.6) | 139 (65.6) | ||
Headache | 0.859 | 0.123 | ||||
Yes | 18 (5.7) | 45 (11.9) | 3 (2.8) | 15 (7.1) | ||
No | 300 (94.3) | 45.6 (12) | 103 (97.2) | 197 (92.9) | ||
Other forms of illness | 0.001 ** | 0.119 | ||||
Yes | 33 (10.4) | 51.5 (9.2) | 7 (6.6) | 26 (12.3) | ||
No | 285 (89.6) | 44.3 (12) | 99 (93.4) | 186 (87.7) | ||
Sleep disturbances | 0.144 | 0.112 | ||||
Yes | 10 (3.1) | 50.5 (10.1) | 1 (0.9) | 9 (4.2) | ||
No | 308 (96.9) | 44.9 (12) | 105 (99.1) | 203 (95.8) | ||
Alteration in smell | 0.844 | 0.625 | ||||
Yes | 38 (11.9) | 44.7 (11.8) | 14 (13.2) | 24 (11.3) | ||
No | 280 (88.1) | 45.1 (12) | 92 (86.8) | 188 (88.7) | ||
Alteration in taste | 0.390 | 0.755 | ||||
Yes | 22 (6.9) | 43 (10.4) | 8 (7.6) | 14 (6.6) | ||
No | 296 (93.1) | 45.2 (12) | 98 (92.4) | 198 (93.4) | ||
Dizziness and loss of concentration | 0.947 | 0.158 | ||||
Yes | 17 (5.3) | 44.9 (11.0) | 3 (2.8) | 14 (6.6) | ||
No | 301 (94.7) | 45.1 (12) | 103 (97.2) | 198 (93.4) | ||
Musculoskeletal pain | <0.001 *** | 0.417 | ||||
Yes | 43 (13.6) | 51.7 (8.9) | 12 (11.3) | 31 (14.6) | ||
No | 275 (86.4) | 44 (12) | 94 (88.7) | 181 (85.4) |
Any Post-COVID-19 Symptom n = 182 (n, %) | p | Post-COVID-19 Dyspnea n = 42 (n, %) | p | Post-COVID-19 Fatigue n = 102 (n, %) | p | Post-COVID-19 Musculoskeletal Pain n = 43 (n, %) | p | |
---|---|---|---|---|---|---|---|---|
Any limitation in work activities | 0.002 ** | <0.001 *** | 0.002 ** | |||||
Yes | 33 (18.1) | 26 (9.5) | 80 (29.3) | 0.002 ** | 31 (11.4) | |||
No | 149 (81.9) | 16 (39) | 22 (53.7) | 12 (29.3) | ||||
Pre-existing pneumological disease | 0.381 | <0.001 *** | 0.041 * | 0.374 | ||||
Yes | 17 (65.4) | 11 (10.6) | 13 (50) | 5 (19.2) | ||||
No | 165 (56.5) | 31 (42.3) | 89 (30.5) | 38 (13) | ||||
Pre-existing psychiatric disorder | 0.637 | 0.007 ** | 0.067 | 0.008 ** | ||||
Yes | 4 (66.7) | 3 (50) | 4 (66.7) | 3 (50) | ||||
No | 178 (57.1) | 39 (12.5) | 98 (31.4) | 40 (12.8) | ||||
Normal weight according to BMI | 0.007 ** | 0.036 * | <0.001 *** | <0.001 *** | ||||
Yes | 110 (52.1) | 22 (10.4) | 54 (25.6) | 18 (8.5) | ||||
No | 72 (67.9) | 20 (18.9) | 48 (45.3) | 25 (23.6) | ||||
Any acute symptom | <0.001 *** | 0.004 ** | <0.001 *** | 0.003 ** | ||||
Yes | 174 (64.2) | 42 (15.5) | 100 (36.9) | 43 (15.9) | ||||
No | 8 (17) | 0 | 2 (4.3) | 0 | ||||
Use of medication during acute infection (except for NSAIDs) | <0.001 *** | <0.001 *** | 0.002 ** | 0.127 | ||||
Yes | 108 (48.4) | 22 (23.4) | 42 (44.7) | 17 (18.1) | ||||
No | 74 (78.7) | 20 (9) | 60 (26.9) | 26 (11.7) | ||||
Acute Dyspnea | <0.001 *** | <0.001 *** | <0.001 *** | <0.001 *** | ||||
Yes | 69 (88.5) | 33 (42.3) | 42 (53.8) | 21 (26.9) | ||||
No | 113 (47.1) | 9 (3.8) | 60 (25) | 22 (9.2) | ||||
Acute Fatigue | <0.001 *** | 0.030 * | <0.001 *** | <0.001 *** | ||||
Yes | 134 (75.3) | 30 (16.9) | 87 (48.9) | 35 (19.7) | ||||
No | 48 (34.3) | 12 (8.6) | 15 (10.7) | 8 (5.7) | ||||
Acute musculoskeletal pain | <0.001 *** | 0.019 * | <0.001 *** | <0.001 *** | ||||
Yes | 118 (71.1) | 29 (17.5) | 72 (43.4) | 40 (24.1) | ||||
No | 64 (42.1) | 13 (8.5) | 30 (19.7) | 3 (2) | ||||
Number of acute symptoms (mean±sd) | 5.2 (2.5) | <0.001 *** | 6.2 (2.4) | <0.001 *** | 5.7 (2.3) | <0.001 *** | 6.3 (2.4) | <0.001 *** |
Any Post-COVID-19 Symptom | Post-COVID-19 Dyspnea | Post-COVID-19 Fatigue | Post-COVID-19 Musculoskeletal Pain | |||||
---|---|---|---|---|---|---|---|---|
Exp (B), 95% CI | p | Exp (B), 95% CI | p | Exp (B), 95% CI | p | Exp (B), 95% CI | p | |
Age | 1.0 [0.99–1.03] | 0.519 | 1 [0.963–1.04] | 0.995 | 1.01 [0.99–1.04] | 0.271 | 1.059 [1.02–1.1] | 0.004 ** |
Number of acute symptoms | -- | -- | 1.09 [0.904–1.32] | 0.434 | 1.24 [1.09–1.41] | 0.001 ** | 1.22 [1.03–1.45] | 0.022 * |
Dyspnea | 5.16 [2.4–11.3] | <0.001 *** | 13.89 [4.89–39.47] | <0.001 *** | -- | -- | -- | -- |
Fatigue | 3.86 [2.2–6.8] | <0.001 *** | -- | -- | 4.00 [1.91–8.38] | <0.001 *** | -- | -- |
Musculoskeletal pain | 1.59 [0.91–2.78] | 0.107 | -- | -- | -- | -- | 8.3 [2.30–30.89] | 0.002 ** |
Normal weight according to BMI | 0.63 [0.36–1.12] | 0.119 | -- | -- | 0.47 [0.27–0.84] | 0.010 ** | 0.49 [0.23–1.03] | 0.059 |
Limitation in work activities | 2.9 [1–7.3] | 0.025 * | 4.79 [1.70–13.49] | 0.003 ** | 2.31 [1.01–5.28] | 0.048 * | 1.67 [0.66–4.22] | 0.277 |
Pneumological disease | -- | -- | 4.9 [1.53–15.77] | 0.008 ** | -- | -- | -- | -- |
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Lulli, L.G.; Baldassarre, A.; Chiarelli, A.; Mariniello, A.; Paolini, D.; Grazzini, M.; Mucci, N.; Arcangeli, G. Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers. Int. J. Environ. Res. Public Health 2023, 20, 4506. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph20054506
Lulli LG, Baldassarre A, Chiarelli A, Mariniello A, Paolini D, Grazzini M, Mucci N, Arcangeli G. Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers. International Journal of Environmental Research and Public Health. 2023; 20(5):4506. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph20054506
Chicago/Turabian StyleLulli, Lucrezia Ginevra, Antonio Baldassarre, Annarita Chiarelli, Antonella Mariniello, Diana Paolini, Maddalena Grazzini, Nicola Mucci, and Giulio Arcangeli. 2023. "Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers" International Journal of Environmental Research and Public Health 20, no. 5: 4506. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph20054506