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Extensive Placental Methylation Profiling in Normal Pregnancies
 
 
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Correction

Correction: Rondinone et al. Extensive Placental Methylation Profiling in Normal Pregnancies. Int. J. Mol. Sci. 2021, 22, 2136

1
Research Laboratories Coordination Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2
Medical Genetics, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy
3
Laboratory of Medical Genetics, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
4
Department of Brain and Behavioral Sciences, Università di Pavia, 27100 Pavia, Italy
5
Medical Genetics, Department of Health Sciences, Università degli Studi di Milano, 20122 Milano, Italy
6
Bioinformatics and Statistical Genomics Unit, Istituto Auxologico Italiano IRCCS, 20095 Cusano Milanino, Italy
7
Department of Obstetrics and Gynecology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
8
Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
9
Scientific Direction, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(10), 5298; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23105298
Submission received: 15 October 2021 / Accepted: 24 February 2022 / Published: 10 May 2022
(This article belongs to the Special Issue Epigenetics in Metabolic and Neurological Disorders 2.0)
In the original publication [1], there was a mistake in Table 2 and Table 3 as published. In the p-value column, a minus sign was missing at the exponent. The corrected Table 2 and Table 3 appear below. The authors apologize for any inconvenience caused and state that the results and scientific conclusions are unaffected by these changes. The original publication has also been updated.

Reference

  1. Rondinone, O.; Murgia, A.; Costanza, J.; Tabano, S.; Camanni, M.; Corsaro, L.; Fontana, L.; Colapietro, P.; Calzari, L.; Motta, S.; et al. Extensive Placental Methylation Profiling in Normal Pregnancies. Int. J. Mol. Sci. 2021, 22, 2136. [Google Scholar] [CrossRef] [PubMed]
Table 2. Diseases or Functions Annotation from IPA Core Analysis on given gene datasets. The top 10 most significant annotations are shown.
Table 2. Diseases or Functions Annotation from IPA Core Analysis on given gene datasets. The top 10 most significant annotations are shown.
A
Diseases or Functions Annotationp-Value
Leukocyte migration1.52 × 10−16
Cell movement of lymphocytes5.05 × 10−14
Cell movement of mononuclear leukocytes6.30 × 10−14
Quantity of leukocytes7.50 × 10−14
Lymphocyte migration9.59 × 10−14
Quantity of lymphatic system cells1.97 × 10−13
Quantity of lymphocytes5.29 × 10−13
Cell movement of leukocytes6.80 × 10−13
Proliferation of blood cells1.21 × 10−12
Proliferation of immune cells1.62 × 10−12
B
Diseases or Functions Annotationp-Value
Cutaneous melanoma1.52 × 10−12
Skin tumor5.94 × 10−12
Melanoma1.01 × 10−11
Skin cancer1.20 × 10−11
Malignant neuroendocrine neoplasm2.45 × 10−7
Small cell lung carcinoma3.07 × 10−7
Olfactory response3.73 × 10−7
Neuroendocrine tumor4.48 × 10−7
Extrapancreatic neuroendocrine tumor5.84 × 10−7
Blue round small cell tumor7.16 × 10−6
(A) Functions identified from gene promoters methylated in the placenta but not in cord blood. (B) Functions identified from gene promoters methylated in cord blood but not in the placenta.
Table 3. Diseases or Functions Annotations in common between methylation-profiling microarray data and targeted methylation sequencing data (data from IPA Core Analysis).
Table 3. Diseases or Functions Annotations in common between methylation-profiling microarray data and targeted methylation sequencing data (data from IPA Core Analysis).
A
Diseases or Functions Annotationp-Value (Microarray)p-Value (Methyl-Seq)
Leukocyte migration2.93 × 10−264.53 × 10−7
Quantity of lymphatic system cells3.30 × 10−25 4.34 × 10−6
Quantity of leukocytes1.51 × 10−25 3.42 × 10−6
Quantity of lymphocytes1.53 × 10−24 4.75 × 10−6
Cell movement of leukocytes5.69 × 10−23 1.38 × 10−10
Activation of cells2.86 × 10−225.05 × 10−14
Migration of cells1.08 × 10−217.35 × 10−7
Proliferation of lymphatic system cells1.68 × 10−211.62 × 10−6
Proliferation of lymphocytes5.96 × 10−212.09 × 10−6
Proliferation of immune cells3.46 × 10−201.58 × 10−6
B
Diseases or Functions Annotationp-Value (Microarray)p-Value (Methyl-Seq)
Cross-linkage of protein1.60 × 10−48.28 × 10−4
Skin carcinoma7.37 × 10−4 3.95 × 10−3
Skin squamous cell carcinoma9.61 × 10−42.69 × 10−4
Relaxation of heart ventricle1.03 × 10−35.24 × 10−3
Surface area of ventricular myocytes1.22 × 10−36.15 × 10−3
Gastro-esophageal carcinoma3.77 × 10−32.78 × 103
Chemosensitivity of glioblastoma cells4.03 × 10−39.20 × 10−3
Pancreatic lesion5.88 × 10−36.34 × 10−3
Formation of solid tumor5.90 × 10−31.74 × 10−3
(A) Top 10 functions identified from gene promoters methylated in placenta but not in cord blood. (B) Functions identified from gene promoters methylated in cord blood but not in placenta. (Only 9 common annotations were found.)
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MDPI and ACS Style

Rondinone, O.; Murgia, A.; Costanza, J.; Tabano, S.; Camanni, M.; Corsaro, L.; Fontana, L.; Colapietro, P.; Calzari, L.; Motta, S.; et al. Correction: Rondinone et al. Extensive Placental Methylation Profiling in Normal Pregnancies. Int. J. Mol. Sci. 2021, 22, 2136. Int. J. Mol. Sci. 2022, 23, 5298. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23105298

AMA Style

Rondinone O, Murgia A, Costanza J, Tabano S, Camanni M, Corsaro L, Fontana L, Colapietro P, Calzari L, Motta S, et al. Correction: Rondinone et al. Extensive Placental Methylation Profiling in Normal Pregnancies. Int. J. Mol. Sci. 2021, 22, 2136. International Journal of Molecular Sciences. 2022; 23(10):5298. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23105298

Chicago/Turabian Style

Rondinone, Ornella, Alessio Murgia, Jole Costanza, Silvia Tabano, Margherita Camanni, Luigi Corsaro, Laura Fontana, Patrizia Colapietro, Luciano Calzari, Silvia Motta, and et al. 2022. "Correction: Rondinone et al. Extensive Placental Methylation Profiling in Normal Pregnancies. Int. J. Mol. Sci. 2021, 22, 2136" International Journal of Molecular Sciences 23, no. 10: 5298. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23105298

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