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Communication

N-Heterocyclic Carbene Adducts of Alkynyl Functionalized 1,3,2-Dithioborolanes

by
Richard Böser
,
Lars Denker
and
René Frank
*
Department of Inorganic and Analytical Chemistry, Faculty of Life Sciences, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(9), 1690; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24091690
Submission received: 4 April 2019 / Revised: 25 April 2019 / Accepted: 29 April 2019 / Published: 30 April 2019
(This article belongs to the Special Issue Boron Chemistry and Its Development in the 21st Century: In Memory of Professor Bohumil Štíbr (1940-2020))
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Abstract

:
Alkynyl functionalized boron compounds are versatile intermediates in the areas of medicinal chemistry, materials science, and optical materials. In particular, alkynyl boronate esters [R1−C≡C−B(OR2)2] are of interest since they provide reactivity at both the alkyne entity, with retention of the B−C bond or alkyne transfer to electrophilic substrates with scission of the latter. The boron atom is commonly well stabilized due to (i) the extraordinary strength of two B−O bonds, and (ii) the chelate effect exerted by a bifunctional alcohol. We reasoned that the replacement of a B−O for a B−S bond would lead to higher reactivity and post-functionalization in the resulting alkynyl boronate thioesters [R1−C≡C−B(S2X)]. Access to this poorly investigated class of compounds starts form chloro dithioborolane cyclo-Cl−B(S2C2H4) as a representative example. Whereas syntheses of three coordinate alkynyl boronate thioesters [R1−C≡C−B(S2X)] proved to be ineffective, the reactions of NHC-adducts (NHC = N-heterocyclic carbene) of cyclo-Cl-B(S2C2H4) afforded the alkyne substituted thioboronate esters in good yield. The products NHC−B(S2C2H4)(C≡C-R1) are remarkably stable towards water and air, which suggests their use as boron-based building blocks for applications akin to oxygen-based boronate esters.

Graphical Abstract

1. Introduction

Alkynyl boronates [R1−C≡C−B(OR2)2] and alkynyl borates [R1−C≡C−B(OR2)3]− (R1, R2 = hydrocarbyl moieties) can be viewed as ester of the parent alkynyl boronic acids R1-C≡C-B(OH)2 and are versatile building blocks, which are widely employed as intermediates for various applications in the areas of medicinal chemistry, materials science, and optical materials [1,2,3]. The key reactivity of these compounds includes (i) transformations at the alkyne entity retaining the B−C bond to afford borylated target compounds, or ii) the transfer of the alkyne moiety to electrophilic reagents with scission of the B−C bond [4,5,6,7,8,9]. Alkynyl boronates can be prepared from monovalent alcohols [10,11], but due to their increased hydrolytic stability the incorporation of bifunctional chelating alcohols, in particular 1,2-dihydroxy compounds, is highly preferred. Thus, the bivalent alcohols introduce a bridging backbone leading to improved stability, and the scope of 1,2-diols employed for alkynyl boronate esters includes pinacol (1) [12,13,14,15,16,17,18,19], catechol, (2) [20,21,22], and ethylene glycol (3) [23,24], Scheme 1. These compounds 1–3 may also be considered as boron substituted heterocycles and can be viewed as derivatives of the parent 1,3,2-dioxaborolane. Whereas oxygen is well established as a flanking neighbor atom at boron centers, the heavier chalcogen sulfur is less common. As indicated by the trend of bonds dissociation energies (BDE) for B−S (577 kJ/mol) vs. B−O bonds (810 kJ/mol) [25],the respective alkynyl boronate thioester (or 1,3,2-dithiaborolane) derivatives are expected to be more reactive in terms of B−S bond scission, which offers options for post-functionalization at the boron center [26]. In contrast to 1,3,2-dioxaborolane derivatives 1–3, the analogous sulfur derivatives have been described in only one previous report in the form of 1,3,2-benzodithiaborole 4 containing an aromatic rigid scaffold [27]. Therefore, we were interested in broadening the scope of alkynyl 1,3,2-dithiaborolanes to an aliphatic backbone as a consistent extension of the oxygen-based 1,3,2-dioxaborolane formulate compounds of type 5 as target structures, Scheme 2.

2. Results

Since the series of compounds 4 could be prepared in acceptable yields (50%–65%) from halogenated 1,3,2-benzodithiaborole, we attempted to employ the established synthetic methodology for our target molecules 5 [27]. In analogous fashion, we reacted chloro dithiaborolane 6 [28] with a wide selection of silylated and stannylated alkynes. In contrast to the synthesis of compounds 4, the 11B-NMR spectra (NMR = nuclear magnetic resonance)of the crude product only showed various broad signals in the range of 10–70 ppm, and the isolation of single compounds by sublimation or crystallization proved ineffective. Similar results were obtained when 6 was reacted with alkynyl organometallic reagents of more electropositive metals. Reactions performed with the alkynyl lithium reagents R−C≡C−Li (R = SiMe3 or Ph) in toluene (at ambient temperature or −78 °C) gave inseparable mixtures, while Grignard reagents of type R−C≡C−MgX (R = SiMe3 or Ph, X = Cl) in etherical solvents [Et2O, THF (tetrahydrofuran) —at ambient temperature or −78 °C] gave even worse results. In part, the latter fact can be rationalized based on decomposition reactions of 6 in etherical solvents observed in the absence of Grignard reagents (i.e., t½ ca. 5 min in Et2O at ambient temperature). Since nucleophilic substitution reactions at boron are known to proceed with higher selectivity for four-coordinate vs. three-coordinate boron compounds, borolane 6 was reacted with representative N-heterocyclic carbenes 7 as strong σ-donor ligands to form the borane adducts 8 [29].
The reactions of 6 with 7 afforded the adducts 8 as colorless, moisture-sensitive solids in analytically pure form. The 11B-NMR signals show a strong high field shift expected for a change from a three-coordinate boron atom in 6 [δ(11B) = 62.9 ppm] to four-fold coordination at boron [δ(11B) = 4.6 ppm (8a), 5.5 ppm (8b)]. X-ray crystallographic analysis for 8a confirmed the bond connectivity, Figure 1i. The ethylene moiety C2H4 in the borolane entity of the products 8 shows only one set of protons appearing as a singlet, although the five-membered ring in the molecular structure of 8a displays half-chair conformation, and diastereotopic protons would be expected in the 1H-NMR spectrum. This is remarkable since the singlet of the ethylene moietyC2H4is split up to two sets of diastereotopic protons in the final products 9 upon introduction of the alkynyl moiety (vide infra). We assumed a dynamic process leading to equivalent proton signals on the NMR-scale. A proposed mechanism is the dissociation of chloride in adducts 8 to give three-coordinate borenium cations of type NHC−B(S2C2H4)+ in low concentration, in which the ethylene protons can rapidly be equilibrated. [30,31] Variable temperature 1H-NMR experiments (CDCl3, −50 °C); however, did not lead to a splitting of the singlet. The 11B-NMR did not reveal any indication of borenium cations, which commonly give broad signals in the low field region. In part, our hypothesis is rationalized based on the mentioned singlet splitting upon substitution of chloride for the alkynyl entity, the latter of which is a poor leaving group. Reactions of NHC-adducts 8 were performed with ethynyl magnesium bromide (H−C≡C−MgBr) as a representative alkyne nucleophile. The salt elimination reactions proceeded with high selectivity and afforded the ethynyl functionalized 1,3,2-dithiaborolanes 9 as colorless solids in good yield. 11B-NMR spectroscopy indicated a significant high field shift upon replacement of chlorine for the ethynyl entity (i.e., 4.6 ppm (8a) → −11.1 ppm (9a), and 5.5 ppm (8b) → −11.5 ppm (9b)). The presence of ethynyl entities in the products 9 is also evident from the IR spectra (IR = infrared), in which diagnostic bands for the γ(C−H) (3220–3310 cm−1) and γ(C≡CH) (~2044 cm−1) appear and indicated the introduction of a terminal alkyne moiety. X-ray crystallographic analysis for 9a and 9b gave further insight into their structures, Figure 1ii,iii.
Upon replacement of chlorine in 8a by the alkyne entity in 9a, the bond lengths of the bound substituents increased, as indicated by the trend of the distances B1−C1 [1.6298(18) Å (8a) → 1.6427(15) Å (9a)] and the averaged distances B1−S [1.9108(14) Å (8a) → 1.9391(12) Å (9a)], which was in line with the reduced electron withdrawing effect of the alkynyl vs. chlorine substituent. The molecular structure of 9a in the solid state revealed an interesting interaction of hydrogen atom H4 of the isopropyl group with the sulfur atom S1 of the dithioborolane cycle. The close contact S1∙∙∙H4 of 2.4620(15) Å and the orientation of the bond C4−H4 perpendicular to S1 in the dithioborolane entity indicated a weak interaction, which is at least due to van der Waals forces but may also result from weak negative hyperconjugation of a p-orbital-based lone pair at sulfur: p(S4) → σ*(C4−H4). This well ordered contact is in accordance with the strong inequality of the B−S bond lengths in 9a (∆d(B−S)~0.06 Å) compared to 9b (∆d(B−S)~0.005 Å), which suggests a more distorted dithioborolane cycle due to additional intramolecular interactions. Although unambiguously observed in the solid state, this bond contact is absent in solution since the NMR-spectra of compound 9a display the expected Cs-symmetry. An inspection of the bond lengths C1−B1 retrieves a slightly longer distance in 9a (1.6427(15) Å) than in 9b (1.6335(19) Å). This trend is expected with the higher nucleophilicity and donating ability of the N-heterocyclic carbene 7a [32], resulting to give more expanded orbitals and, thus, longer bond distances at the carbene carbon atom.

3. Discussion

In an attempt to expand the scope of alkynyl borate thioesters [R1−C≡C−B(S2X)] from currently known compounds 4 with an aromatic backbone, we applied established routes to produce the novel alkynyl borate thioesters 5 with a saturated, aliphatic backbone. However, reactions starting from chloro dithioborolane 6 proved to be ineffective and gave inseparable mixtures of various products, as indicated by 11B-NMR spectroscopy of crude products. In contrast, adducts of 6 with N-heterocyclic carbenes (8) selectively react with ethynyl magnesium bromide (H−C≡C−MgBr) to afford alkynyl substituted adducts of dithioborolanes (9) with the aliphatic backbone in good yield. The products 9 appeared remarkably stable in air and even tolerated the work-up at aqueous conditions, which is an important aspect for future facile applications. In particular, the stability of the B−S bonds towards hydrolytic cleavage is noteworthy. Future investigation of compounds 9 will focus on the methods to further functionalize the B−S bonds with moieties of interest related to applications in materials science.

4. Materials and Methods

4.1. General Remarks

All procedures involving air or moisture sensitive compounds were performed under dry argon atmosphere using Schlenk techniques or in a glove box (MBraun 200B). Solvents were purified and dried using a solvent purification system (Braun) and stored over molecular sieve (3–4 Å). All commercially available compounds [TCI (Germany), abcr-GmbH (Karlsruhe, Germany), deutero-GmbH (Kastellaun, Germany), Sigma Aldrich (Germany)] were used without further purification. The compounds cyclo-ClBS2C2H4 (6) [28], IiPr (7a) [33], and IMes (7b) [34] were prepared according to literature methods.

4.2. Analytical Methods

NMR spectra were recorded on Bruker Avance II-300, Avance III-HD, Avance III-400, and AVII-600. The chemical shifts (δ) are reported in parts per million (ppm). The residual solvent peak (CHCl3, δ = 7.26 ppm) was used for referencing of the 1H spectra. The 13C spectra were internally calibrated by using the 13C resonances of the solvent peaks (CDCl3, δ = 77.16 ppm). For 11B NMR an external calibration with BF3·Et2O was used. Coupling constants are stated in Hertz (Hz), multiplicities are defined as br (broad), s (singlet), d (doublet), t (triplet), q (quartet), sept (septett), dd (doublet of doublets), dsept (doublet of septets), tt (triplet of triplets), tq (triplet of quartets), ddd (doublet of doublet of doublets), qdq (quartet of doublet of quartets), or m (multiplet). 2D NMR experiments (H,C-HSQC, H,C-HMBC) or gated-13C NMR experiments were used to aid the assignment of the signals.
Elemental analyses were accomplished by combustion and gas chromatographic analysis using a VarioMICRO Tube and thermal conductivity detection. Values are reported in %. GC-MS (gas chromatography coupled to mass spectroscopy) were recorded on a Finnigan MAT 8400-MSS I, Finnigan MAT 4515 using the EI (electron ionization) method. Values are reported as observed m/z ratio.Details for the X-ray crystallographic analysis of compounds 8a, 9a, and 9b are summarized in the section “Supporting Information”.

4.3. Synthetic Procedures

4.3.1. Compound 8a

IiPr (7a, 400 mg, 2.63 mmol) in toluene (50 mL) was added dropwise to a solution of chloro dithioborolane (6, 450 mg, 3.28 mmol) in toluene (25 mL) at 0 °C. After stirring for 10 min at room temperature, the reaction mixture was dried in vacuo. The rose solid was dissolved in THF (tetrahydrofuran, 5 mL) and precipitated with pentane (20 mL). After filtration and drying in vacuo the product was obtained as a light rose solid (65% yield). Crystals suitable for X-ray crystallography were obtained by slow solvent diffusion of hexane into a solution of the product in toluene.
1H NMR (500.3 MHz, CDCl3): δ (ppm) = 7.09 (s, 2 H, NCH), 5.79 [sept, 2 H, CH(CH3)2, 3JHH = 6.7 Hz], 3.12 (s, 4 H, CH2), 1.48 (d, 12 H, CH3, 3JHH = 6.7 Hz).
13C{1H} NMR (125.8 MHz, CDCl3): δ (ppm) = 156.3 (m, NCN), 117.4 (s, NCH), 51.4 [s, C(CH3)2], 37.5 (s, CH2), 23.7 (s, CH3).
11B{1H} NMR (160.5 MHz, CDCl3): δ (ppm) = 4.6 (s, ω½ = 45 Hz).
Elemental Analysis: Calcd. for C11H20BClN2S2: C 45.45, H 6.94, N 9.64, S 22.06. Found: C 45.58, H 6.97, N 9.42, S 22.15.

4.3.2. Compound 8b

IMes (7b, 1.61 g, 5.28 mmol) in toluene (15 mL) was added to a solution of chloro dithioborolane (6, 730 mg, 5.28 mmol) in toluene (10 mL) at 0 °C. A bright yellowish solid was precipitated. The reaction mixture was stirred for 30 min at room temperature. After filtration, washing with toluene (30 mL) and subsequent drying in vacuo, the product was obtained as a white solid (93% yield). If required, further purification can be performed by slow diffusion of pentane into a solution of the crude product in CHCl3.
1H NMR (600.1 MHz, CDCl3): δ (ppm) = 7.10 (s, 2 H, NCH), 7.01 (s, 4 H, Mes-CH), 2.77 (s, 4 H, CH2), 2.36 (s, 6 H, Mes-para-CH3), 2.21 (s, 12 H, Mes-ortho-CH3).
13C{1H} NMR (150.9 MHz, CDCl3): δ (ppm) = 158.4 (m, NCN), 140.7 (s, Mes-ipso-C), 136.1 (s, Mes-para-C), 133.5 (s, Mes-ortho-C), 129.4 (s, Mes-meta-CH), 123.3 (s, NCH), 37.3 (s, CH2), 21.4 (s, Mes-para-CH3), 18.5 (s, Mes-ortho-CH3).
11B{1H} NMR (128.5 MHz, CDCl3): δ (ppm) = 5.5 (s, ω½ = 80 Hz).
Elemental Analysis: Calcd. for C23H28BClN2S2: C 62.38, H 6.37, N 6.33, S 14.48. Found: C 62.04, H 6.16, N 5.89, S 14.25.

4.3.3. Compound 9a

Ethynyl magnesium bromide (H−C≡C−MgBr, 1.52 mL, 0.5 M in THF, 0.76 mmol) was added dropwise to a solution of compound 8a (200 mg, 0.69 mmol) in THF (20 mL) at 0 °C. After stirring for 15 min at 0 °C and 1 h at room temperature the reaction mixture was dried in vacuo. The remaining solids were dissolved in DCM (20 mL) and washed with distilled water (3 × 20 mL). The organic phase was dried over MgSO4, filtrated, and dried to yield the product as a light beige solid (75%). Crystals suitable for X-ray crystallography were obtained by storing a solution of the product in toluene at −30 °C.
1H NMR (500.3 MHz, CDCl3): δ (ppm) = 7.05 (s, 2 H, NCH), 6.07 [sept, 2 H, CH(CH3)2, 3JHH = 7.0 Hz], 3.22–2.94 (m, 4 H, CH2), 2.58 (s, 1H, CCH), 1.46 (d, 12 H, CH3, 3JHH = 7.0 Hz).
13C{gated-1H} NMR (125.8 MHz, CDCl3): δ (ppm) = 158.1 (br q, NCN, 1JBC = 62.2 Hz, 1JBC = 73.8 Hz), 117.3 (ddd, NCH, 1JCH = 194.7 Hz, 2JCH = 11.2 Hz, 3JCH = 4.7 Hz), 99.2 (m, CCH), 85.9 (br d, CCH, 1JCH = 238.7 Hz), 50.4 (dsept, C(CH3)2, 1JCH = 144.6 Hz, 2JCH = 4.2 Hz), 38.0 (tt, CH2, 1JCH = 140.3 Hz, 2JCH = 2.1 Hz), 23.7 (qdq, CH3, 1JCH = 127.9 Hz, 2JCH = 4.5 Hz, 3JCH = 4.5 Hz).
11B{1H} NMR (160.5 MHz, CDCl3): δ (ppm) = −11.1 (s, ω½ = 19 Hz).
Elemental Analysis: Calcd. for C13H21BN2S2: C 55.71, H 7.55, N 10.00, S 22.88. Found: C 56.03, H 7.68, N 10.14, S 22.74.
MS (EI): m/z = 280.12 [M]+, 128.0 [M − IiPr]+.
IR (ATR, cm−1): diagnostic band v ~ = 3306 [w, γ(CC-H)].

4.3.4. Compound 9b

Ethynyl magnesium bromide (H−C≡C−MgBr, 6.4 mL, 0.5 M in THF, 3.2 mmol) was added dropwise to a solution of compound 8b (1.28 g, 2.9 mmol) in THF (80 mL) at 0 °C. After stirring for 30 min at 0 °C and 1 h at room temperature the reaction mixture was dried in vacuo. The remaining solids were dissolved in DCM (dichloromethane, 150 mL) and washed with distilled water (3 × 150 mL). The organic phase was dried over MgSO4, filtrated, and dried to yield the product as a beige solid (71%). Crystals suitable for X-ray crystallography were obtained by gas phase diffusion of pentane into a solution of the product in CDCl3.
1H NMR (600.1 MHz, CDCl3): δ (ppm) = 7.00 (s, 2 H, NCH), 6.96 (s, 4 H, Mes-CH), 2.77–2.37 (m, 4 H, CH2), 2.33 (s, 6 H, Mes-para-CH3), 2.21 (s, 12 H, Mes-ortho-CH3), 2.04 (s, 1 H, CCH).
13C{gated-1H} NMR (150.9 MHz, CDCl3): δ (ppm) = 161.8 (br q, NCN, 1JBC = 61.0 Hz, 1JBC = 72.8 Hz), 141.1 (q, Mes-ipso-C, 3JCH = 6.0 Hz), 139.7 (q, Mes-para-C, 2JCH = 6.0 Hz), 135.5 (q, Mes-ortho-C, 2JCH = 6.0 Hz), 128.7 (m, Mes-meta-CH), 124.4 (dd, NCH, 1JCH = 198.5 Hz, 2JCH = 11.4 Hz), 97.4 (m, CCH), 85.6 (d, CCH, 1JCH = 234.8 Hz), 37.3 (tt, CH2, 1JCH = 140.1 Hz, 2JCH = 2.8 Hz), 20.9 (tq, Mes-para-CH3, 1JCH = 126.5 Hz, 3JCH = 4.7 Hz), 18.2 (m, Mes-ortho-CH3).
11B{1H} NMR (160.5 MHz, CDCl3): δ (ppm) = −11.5 (s, ω½ = 30 Hz).
Elemental Analysis: Calcd. for C25H29BN2S2: C 69.43, H 6.76, N 6.48, S 14.83. Found: C 68.98, H 6.77, N 6.39, S 14.65.
MS (EI): m/z = 432.19 [M]+, 128.0 [M − IMes]+.
IR (ATR, cm−1): diagnostic bands v ~ = 3225 [w, γ(CC-H)], 2044 [w, γ(C≡C)].

Supplementary Materials

The section “Supporting Information” containing crystallographic details as well as graphic illustrations of the NMR and IR spectra is available online.

Author Contributions

Synthetic work, purification of target compounds, R.B. (90%), L.D. (10%); crystallographic analysis, manuscript preparation, R.B.; project administration and supervision, R.F.

Funding

This research was funded by the “Fonds der Chemischen Industrie (FCI)” and the “Deutsche Forschungsgemeinschaft DFG”. Both organizations are highly acknowledged for their generous financial support of the research. We also express our thanks to the “Publikationsfonds der TU Braunschweig” for the payment of the costs for the publication.

Conflicts of Interest

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Molecules 24 01690 sch001 550
Scheme 1. Selection of widely employed alkynyl boronate esters of divalent vicinal alcohols (1–3, left) and the rare examples of alkynyl boronate thioesters with benzene-1,2-dithiol backbone (4, right).
Scheme 1. Selection of widely employed alkynyl boronate esters of divalent vicinal alcohols (1–3, left) and the rare examples of alkynyl boronate thioesters with benzene-1,2-dithiol backbone (4, right).
Molecules 24 01690 sch001
Molecules 24 01690 sch002 550
Scheme 2. Synthetic routes towards alkynyl 1,3,2-dithiaborolanes.
Scheme 2. Synthetic routes towards alkynyl 1,3,2-dithiaborolanes.
Molecules 24 01690 sch002
Molecules 24 01690 g001 550
Figure 1. Molecular structures of compounds 8a (CCDC1907368), 9a (CCDC 1907369), and 9b (CCDC 1907370). The code numbers denote the entry of the data deposited at the Cambridge Crystallographic Data Centre. Ellipsoids drawn at the 50% probability level. Hydrogen atoms of minor relevance and solvents are omitted for clarity. Selected bond lengths (Å) and angles (°). (i) 8a: B1−C1 1.6298(18), B1−S1 1.9198(14), B1−S2 1.9018(14), B1−Cl1 1.9074(14), C1−B1−Cl1 105.98(9), C1−B1−S1 106.65(8), C1−B1−S2 119.60(9), N2−C1−B1-S1 113.01(13). (ii) 9a: C1−B1 1.6427(15), B1−S1 1.9140(12), B1−S2 1.9642(12), B1−C10 1.5754(16), C10−C11 1.1975(18), C1−B1−C10 109.04(9), C1−B1−S1 118.69(7), C1−B1−S2 106.20(7), N1−C1−B1−C10 124.80(12). (iii) 9b: B1−C1 1.6335(19), B1−S1 1.9397(15), B1−S2 1.9343(15), B1−C24 1.5811(19), C24−C25 1.201(2), C1−B1−C24 113.14(11), C1−B1–S1 113.13(9), C1−B1−S2 108.08(9), N1−C1−B1−C24 176.64(12).
Figure 1. Molecular structures of compounds 8a (CCDC1907368), 9a (CCDC 1907369), and 9b (CCDC 1907370). The code numbers denote the entry of the data deposited at the Cambridge Crystallographic Data Centre. Ellipsoids drawn at the 50% probability level. Hydrogen atoms of minor relevance and solvents are omitted for clarity. Selected bond lengths (Å) and angles (°). (i) 8a: B1−C1 1.6298(18), B1−S1 1.9198(14), B1−S2 1.9018(14), B1−Cl1 1.9074(14), C1−B1−Cl1 105.98(9), C1−B1−S1 106.65(8), C1−B1−S2 119.60(9), N2−C1−B1-S1 113.01(13). (ii) 9a: C1−B1 1.6427(15), B1−S1 1.9140(12), B1−S2 1.9642(12), B1−C10 1.5754(16), C10−C11 1.1975(18), C1−B1−C10 109.04(9), C1−B1−S1 118.69(7), C1−B1−S2 106.20(7), N1−C1−B1−C10 124.80(12). (iii) 9b: B1−C1 1.6335(19), B1−S1 1.9397(15), B1−S2 1.9343(15), B1−C24 1.5811(19), C24−C25 1.201(2), C1−B1−C24 113.14(11), C1−B1–S1 113.13(9), C1−B1−S2 108.08(9), N1−C1−B1−C24 176.64(12).
Molecules 24 01690 g001

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Böser, R.; Denker, L.; Frank, R. N-Heterocyclic Carbene Adducts of Alkynyl Functionalized 1,3,2-Dithioborolanes. Molecules 2019, 24, 1690. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24091690

AMA Style

Böser R, Denker L, Frank R. N-Heterocyclic Carbene Adducts of Alkynyl Functionalized 1,3,2-Dithioborolanes. Molecules. 2019; 24(9):1690. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24091690

Chicago/Turabian Style

Böser, Richard, Lars Denker, and René Frank. 2019. "N-Heterocyclic Carbene Adducts of Alkynyl Functionalized 1,3,2-Dithioborolanes" Molecules 24, no. 9: 1690. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24091690

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