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Article

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates

by
Danylo KAMINSKYY
1,
Dmytro KHYLUK
1,
Olexandr VASYLENKO
2,
Lucjusz ZAPRUTKO
3 and
Roman LESYK
1,*
1
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
2
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Murmanska 1, 02094, Kyiv, Ukraine
3
Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(4), 763-778; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1109-14
Submission received: 19 September 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
Versions Notes

Abstract

The synthesis and evaluation of the anticancer activity of 3’-aryl-5’-arylidene-spiro[3H-indole-3,2’-thiazolidine]-2,4’(1H)-diones and spiro[3H-indole-3,2’-thi-azolidine]-2,4’(1H)-dione-3’-alkanoic acid esters were described. The structure of the compounds was determined by 1H and 13C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.
Keywords: Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine] Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine]

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MDPI and ACS Style

KAMINSKYY, D.; KHYLUK, D.; VASYLENKO, O.; ZAPRUTKO, L.; LESYK, R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Sci. Pharm. 2011, 79, 763-778. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1109-14

AMA Style

KAMINSKYY D, KHYLUK D, VASYLENKO O, ZAPRUTKO L, LESYK R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Scientia Pharmaceutica. 2011; 79(4):763-778. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1109-14

Chicago/Turabian Style

KAMINSKYY, Danylo, Dmytro KHYLUK, Olexandr VASYLENKO, Lucjusz ZAPRUTKO, and Roman LESYK. 2011. "A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates" Scientia Pharmaceutica 79, no. 4: 763-778. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1109-14

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