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Volume 80
Issue 3
10.3797/scipharm.1204-23
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Article

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives

by
Manal M. KANDEEL
,
Lamia W. MOHAMED
*,
Mohammed K. ABD EL HAMID
and
Ahmed T. NEGMELDIN
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(3), 531-546; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1204-23
Submission received: 23 April 2012 / Accepted: 25 June 2012 / Published: 25 June 2012
Versions Notes

Abstract

A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4-yl]hydrazone (VIIa) was found to be the most effective among the other derivatives, showing IC50 values of 0.326 to 4.31 μM on 57 different cell lines.
Keywords: Pyrazolopyrimidines; Antitumor Activity; Cytotoxic Activity; Synthesis Pyrazolopyrimidines; Antitumor Activity; Cytotoxic Activity; Synthesis

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MDPI and ACS Style

KANDEEL, M.M.; MOHAMED, L.W.; ABD EL HAMID, M.K.; NEGMELDIN, A.T. Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives. Sci. Pharm. 2012, 80, 531-546. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1204-23

AMA Style

KANDEEL MM, MOHAMED LW, ABD EL HAMID MK, NEGMELDIN AT. Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives. Scientia Pharmaceutica. 2012; 80(3):531-546. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1204-23

Chicago/Turabian Style

KANDEEL, Manal M., Lamia W. MOHAMED, Mohammed K. ABD EL HAMID, and Ahmed T. NEGMELDIN. 2012. "Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives" Scientia Pharmaceutica 80, no. 3: 531-546. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1204-23

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