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Sci. Pharm.
Volume 83
Issue 3
10.3797/scipharm.1505-06
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Improved Automated Radiosynthesis of [11C]PBR28

by
Kiran Kumar SOLINGAPURAM SAI
1,*,
Don GAGE
1,
Mike NADER
2,
Robert H. MACH
3 and
Akiva MINTZ
1
1
Department of Radiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
2
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
3
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(3), 413-427; https://doi.org/10.3797/scipharm.1505-06
Submission received: 7 May 2015 / Accepted: 19 June 2015 / Published: 19 June 2015
Versions Notes

Abstract

Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [11C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates. In this study, we optimized the radiolabeling procedure of [11C]PBR28 for higher radiochemical yield, radiochemical purity, and specific activity, which can be easily translated to any automated module for clinical trials. Time-activity curves (TACs) derived from the dynamic PET imaging of male rhesus monkey brains demonstrated that [11C]PBR28 had suitable kinetics with radiotracer accumulation observed in the caudate, putamen, cerebellum, and frontal cortex region.
Keywords: Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO

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MDPI and ACS Style

SOLINGAPURAM SAI, K.K.; GAGE, D.; NADER, M.; MACH, R.H.; MINTZ, A. Improved Automated Radiosynthesis of [11C]PBR28. Sci. Pharm. 2015, 83, 413-427. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1505-06

AMA Style

SOLINGAPURAM SAI KK, GAGE D, NADER M, MACH RH, MINTZ A. Improved Automated Radiosynthesis of [11C]PBR28. Scientia Pharmaceutica. 2015; 83(3):413-427. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1505-06

Chicago/Turabian Style

SOLINGAPURAM SAI, Kiran Kumar, Don GAGE, Mike NADER, Robert H. MACH, and Akiva MINTZ. 2015. "Improved Automated Radiosynthesis of [11C]PBR28" Scientia Pharmaceutica 83, no. 3: 413-427. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1505-06

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